| Study of the influence of alkalizing components on matrix pellets prepared by extrusion/spheronization. | |
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MedLine Citation:
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PMID: 21067337 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The aim of this study was to investigate the effects of alkalizing components and the nature of the wetting liquid on the properties of matrix pellets prepared by extrusion and spheronization. Atenolol was used as an active pharmaceutical ingredient, ethylcellulose as a matrix former, microcrystalline cellulose as a filler and disodium phosphate anhydrous and trisodium phosphate dodecahydrate as alkalizing materials. Water and a water-ethanol mixture served as granulation liquids. Pellet formation was evaluated via mechanical, dissolution and morphological studies. In order to enhance the dissolution of Atenolol from the pellets, alkalizing components were used and the influence of these components on the pH was tested. Investigations of the breaking hardness, the morphology and the dissolution revealed that the pellets containing trisodium phosphate dodecahydrate and prepared with a higher amount of water as binding liquid displayed the best physico-chemical parameters and uniform dissolution. In in vitro experiments, the dissolution release complied with the texture of the pellets and the effect of pH. The pellets have suitable shape and very good hardness for the coating process and are appropriate for subsequent in vivo experiments. |
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Authors:
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Elnazeer I Hamedelniel; János Bajdik; Péter Kása; Klára Pintye-Hódi |
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Publication Detail:
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Type: Journal Article Date: 2010-11-10 |
Journal Detail:
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Title: Pharmaceutical development and technology Volume: 17 ISSN: 1097-9867 ISO Abbreviation: Pharm Dev Technol Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-02-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9610932 Medline TA: Pharm Dev Technol Country: England |
Other Details:
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Languages: eng Pagination: 204-11 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutical Technology, University of Szeged , Szeged , Hungary. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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