Document Detail

Study of the incidence of hypospadias in Rochester, Minnesota, 1940-1970, and a case-control comparison of possible etiologic factors.
MedLine Citation:
PMID:  4855617     Owner:  NLM     Status:  MEDLINE    
A community-wide (Rochester, Minnesota), case-control study of the incidence severity, trends, and possible etiologic factors, both environmental and genetic, of hypospadias, between 1940-1970, is presented. Of 13,776 live male births, 113 cases 8.2/1000) of hypospadias were found. There was no significant variation in the rates by 5-year periods and no cyclic pattern noted. In 7 instances, 2 brothers were affected, and in 4 families, the father was also affected. There was no difference between index and control mothers with respect to drug usage. Hydroxyprogesterone caproate, i.m., had been given to 4 index mothers and 1 control mother, 3 index mothers had received thyroid therapy during the first trimester, 1 index mother and 4 control mothers had received meclizine, 4 control mothers had received estrogen, and 9 index mothers and 5 control mothers had taken oral contraceptives (combination) within 9 months of their last menstrual period. There was a larger proportion of testicular anomalies which might have adversely affected spermatogenesis and semen quality among index fathers than among control fathers. These data suggest a multifactorial etiology of hypospadias fitting a polygenic model.
R A Sweet; H G Schrott; R Kurland; O S Culp
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Mayo Clinic proceedings     Volume:  49     ISSN:  0025-6196     ISO Abbreviation:  Mayo Clin. Proc.     Publication Date:  1974 Jan 
Date Detail:
Created Date:  1974-03-02     Completed Date:  1974-03-02     Revised Date:  2013-12-13    
Medline Journal Info:
Nlm Unique ID:  0405543     Medline TA:  Mayo Clin Proc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  52-8     Citation Subset:  IM; J    
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MeSH Terms
Hypospadias / epidemiology*,  etiology,  genetics
Infant, Newborn
Information Systems
Penis / abnormalities
Population Surveillance
Scrotum / abnormalities
Testis / abnormalities

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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