Document Detail


Study of immunoregulating properties of an interferon inducer in animals with various reactions to the antigen
MedLine Citation:
PMID:  2665676     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Influence of dsRNA isolated from killer yeast of S. cerevisiae on humoral and cellular immune responses in mice CBA/CaY and C57Bl/6Y with opposing reaction to the antigen was studied. It was shown that after administration of the yeast dsRNA preparation to the animals simultaneously with the antigen there was an increase in the number of the antibody forming cells in the spleen and the titer of hemolytic antibodies in blood serum of the animals with high and low reactions to the antigen. After sensitization with different doses of sheep red blood cells (10(7) and 10(8)) the preparation had immunomodulating action on development of DTH in mice CBA/CaY. The effect of the dsRNA preparation on the immunity system depended on the preparation dose, antigen loading and animal genotype and was the most marked in mice CBA/CaY with interferon levels in blood serum 2-3 times higher than those in mice C57Bl/6Y.
Authors:
G M Sysoeva; V A Razvorotnev; V A Fadina; A N Kostomakha
Publication Detail:
Type:  Comparative Study; English Abstract; Journal Article    
Journal Detail:
Title:  Antibiotiki i khimioterapii͡a = Antibiotics and chemoterapy [sic] / Ministerstvo meditsinskoĭ i mikrobiologicheskoĭ promyshlennosti SSSR     Volume:  34     ISSN:  0235-2990     ISO Abbreviation:  Antibiot. Khimioter.     Publication Date:  1989 Apr 
Date Detail:
Created Date:  1989-08-21     Completed Date:  1989-08-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8803688     Medline TA:  Antibiot Khimioter     Country:  USSR    
Other Details:
Languages:  rus     Pagination:  276-9     Citation Subset:  IM    
Vernacular Title:
Issledovanie immunoreguliatornykh svoĭstv induktora interferona u oppozitnoreagiruiushchikh na antigen zhivotnykh.
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MeSH Terms
Descriptor/Qualifier:
Adjuvants, Immunologic
Animals
Antibody-Producing Cells / cytology
Antigens / immunology*
Erythrocytes / immunology*
Immunization*
Interferon Inducers / immunology,  pharmacology*
Interferon Type I / biosynthesis*
Mice
Mice, Inbred C57BL
Mice, Inbred CBA
RNA, Double-Stranded / immunology,  pharmacology*
RNA, Fungal / immunology,  pharmacology*
Saccharomyces cerevisiae*
Sheep
Spleen / cytology
Chemical
Reg. No./Substance:
0/Adjuvants, Immunologic; 0/Antigens; 0/Interferon Inducers; 0/Interferon Type I; 0/RNA, Double-Stranded; 0/RNA, Fungal

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