| Study of the hypothermia induced by methionine sulfoximine in the rat. | |
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MedLine Citation:
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PMID: 3252271 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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L-Methionine sulfoximine (MSO) intraperitoneally injected at subconvulsive and convulsive doses induced a rectal hypothermia in the restrained rat maintained at an ambient temperature of 23 degrees C; this hypothermia developed during the preconvulsive period, and it was not suppressed by simultaneous injection of L-methionine which antagonized the behavioral effects of ammonia elevated contents in the central nervous system. The development of rectal hypothermia was faster when the injection of MSO was made into the lateral cerebral ventricle and particularly into the third ventricle. MSO-induced hypothermia seemed to be a poikilothermia-like state in the cold environment with retention of a normal regulation in the heat environment. Infusion of MSO into the anterior hypothalamic/preoptic (AH/PO) area induced a rapid rectal hyperthermia, but infused into the mammillary region MSO had no effect on rectal temperature. It is suggested that rectal hypothermia induced by MSO may be directly related to a depressive effect on glucose oxidative metabolism in cell structures, maybe astroglial cells, located in the vicinity of the ventricle or the capillary walls. |
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Authors:
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M Ginefri-Gayet; J Gayet |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pharmacology, biochemistry, and behavior Volume: 31 ISSN: 0091-3057 ISO Abbreviation: Pharmacol. Biochem. Behav. Publication Date: 1988 Dec |
Date Detail:
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Created Date: 1989-08-01 Completed Date: 1989-08-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0367050 Medline TA: Pharmacol Biochem Behav Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 797-802 Citation Subset: IM |
Affiliation:
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Laboratoire de Physiologie Générale, Faculté des Sciences, Université de Nancy 1, Vandoeuvre-lès-Nancy, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Temperature Regulation / drug effects* Brain / drug effects Hypothermia, Induced* Injections, Intraperitoneal Injections, Intraventricular Male Methionine / pharmacology Methionine Sulfoximine / administration & dosage, pharmacology* Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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1982-67-8/Methionine Sulfoximine; 63-68-3/Methionine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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