Document Detail

Study of the human hypoglossal nucleus: normal development and morpho-functional alterations in sudden unexplained late fetal and infant death.
MedLine Citation:
PMID:  19553043     Owner:  NLM     Status:  MEDLINE    
This study evaluated the development and the involvement in sudden perinatal and infant death of the medullary hypoglossal nucleus, a nucleus that, besides to coordinate swallowing, chewing and vocalization, takes part in inspiration. Through histological, morphometrical and immunohistochemical methods in 65 cases of perinatal and infant victims (29 stillbirths, 7 newborns and 29 infants), who died of both unknown and known cause, the authors observed developmental anomalies of the hypoglossal nucleus (HGN) in high percentage of sudden unexplained fetal and infant deaths. In particular, HGN hypoplasia, hyperplasia, positive expression of somatostatin and absence of interneurons were frequently found particularly in infant deaths, with a significant correlation with maternal smoking.
Anna Maria Lavezzi; Melissa Corna; Rosaria Mingrone; Luigi Matturri
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Publication Detail:
Type:  Journal Article     Date:  2009-06-23
Journal Detail:
Title:  Brain & development     Volume:  32     ISSN:  1872-7131     ISO Abbreviation:  Brain Dev.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-08     Completed Date:  2010-05-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7909235     Medline TA:  Brain Dev     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  275-84     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2009 Elsevier B.V. All rights reserved.
Lino Rossi Research Center for the Study and Prevention of Unexpected Perinatal Death and SIDS-Department of Surgical, Reconstructive and Diagnostic Sciences, University of Milan, Via della Commenda, 19, 20122 Milan, Italy.
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MeSH Terms
Fetal Death* / pathology,  physiopathology
Gestational Age
Infant, Newborn
Medulla Oblongata* / anatomy & histology,  pathology,  physiology
Prenatal Exposure Delayed Effects / pathology
Respiratory Center* / anatomy & histology,  pathology,  physiology
Smoking / adverse effects
Sudden Infant Death* / pathology

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