Document Detail

Study on expression of laminin in patients with intractable epilepsy.
MedLine Citation:
PMID:  19916850     Owner:  NLM     Status:  MEDLINE    
In this study, we examined differences in serum laminin expression in patients with intractable epilepsy. Our results suggest that elevated laminin may contribute to the pathogenesis of intractable epilepsy. ELISA and western blots were used to measure laminin in the serum of 30 intractable epilepsy patients, 46 nonintractable epilepsy patients, and 20 normal subjects. By ELISA, serum laminin levels were greater in intractable epilepsy patients (177.396 +/- 30.602) and nonintractable epilepsy patients (121.915 +/- 35.215) than in normal control subjects (67.474 +/- 7.197); laminin was significantly greater in the intractable epilepsy group than in the nonintractable epilepsy group. In western blots, the optical density ratio of laminin to ss-actin was 0.871 +/- 0.032 for the intractable epilepsy group, 0.686 +/- 0.017 for the nonintractable epilepsy group, and 0.385 +/- 0.024 for the normal control group. The optical density ratios of the intractable and nonintractable epilepsy groups were higher than those for the normal control group, and the intractable epilepsy group was even greater than the nonintractable epilepsy group. Thus, laminin is significantly increased in epilepsy patients, and this increase is more profound in intractable epilepsy patients.
Yuan Wu; Yun Feng; Jia-Rong Pang; Mei Tang; Xiu-Ying Liu; Jia-Quan Li; Xue-Feng Wang
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The International journal of neuroscience     Volume:  119     ISSN:  1563-5279     ISO Abbreviation:  Int. J. Neurosci.     Publication Date:  2009  
Date Detail:
Created Date:  2009-11-17     Completed Date:  2010-01-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0270707     Medline TA:  Int J Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  2219-27     Citation Subset:  IM    
Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
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MeSH Terms
Actins / blood
Analysis of Variance
Blotting, Western
Enzyme-Linked Immunosorbent Assay
Epilepsy / blood*
Laminin / blood*
Middle Aged
Young Adult
Reg. No./Substance:
0/Actins; 0/LAMB1 protein, human; 0/Laminin

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