Document Detail

Study of experiment on leaching of bisphenol A from infant books to artificial saliva.
MedLine Citation:
PMID:  20508389     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the risk of bisphenol A (BPA) exposure when infants suck or chew infant books, the concentration of BPA leaching from infant books published by Japanese makers to artificial saliva was measured.
METHODS: The concentration of BPA leaching from 10 infant books to 15 ml artificial saliva or water was measured at 37 degrees C for 20 hrs. BPA concentration was measured by high-performance liquid chromatography-electrochemical detection (HPLC-ECD) with solid-phase extraction.
RESULTS: BPA was leached from all books when pieces of them were dipped both into saliva and water for 20 hrs. The highest concentration of BPA leaching from one out of 10 books was 43.4 ng/ml (for 2 hrs) in saliva, which was estimated to be approximately 0.052 mg/kg body weight/day for infants aged 6-10 months.
CONCLUSION: As BPA has endocrine-disrupting effects and poses higher risks in infants than in adults, it is desired to reduce BPA use in the printing of infant books from the viewpoint of child health.
Junko Sajiki; Ryoko Yanagibori; Yaeko Kobayashi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nihon eiseigaku zasshi. Japanese journal of hygiene     Volume:  65     ISSN:  0021-5082     ISO Abbreviation:  Nihon Eiseigaku Zasshi     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-28     Completed Date:  2010-08-03     Revised Date:  2011-07-27    
Medline Journal Info:
Nlm Unique ID:  0417457     Medline TA:  Nihon Eiseigaku Zasshi     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  467-70     Citation Subset:  IM    
Chiba Prefectural Institute of Public Health, Nitona-Cho, Chuoku, Chiba, Japan.
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MeSH Terms
Chromatography, High Pressure Liquid
Endocrine Disruptors* / analysis
Phenols* / analysis
Risk Assessment
Saliva, Artificial*
Reg. No./Substance:
0/Endocrine Disruptors; 0/Phenols; 0/Saliva, Artificial; 7732-18-5/Water; 80-05-7/bisphenol A

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