| Study of etiologic relationship of arterial atherosclerosis to corporal veno-occlusive dysfunction in the rabbit. | |
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MedLine Citation:
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PMID: 8627886 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: The aim of this study was to explore the possible etiologic relationship of hypercholesterolemia and atherosclerosis to corporal veno-occlusive dysfunction. MATERIALS AND METHODS: In the New Zealand White rabbit, the competence of the corporal veno-occlusive mechanism was examined at various intervals after exposure to control diet, high cholesterol diet, or aortoiliac atherosclerosis. RESULTS: Initially, all animals showed normal erectile function and corporal veno-occlusion. After 8 weeks and 16 weeks, the control animals preserved normal erection and corporal veno-occlusion, while most of the hypercholesterolemic and atherosclerotic animals developed corporal veno-occlusive dysfunction. The incidence of corporal veno-occlusive dysfunction in the hypercholesterolemia and atherosclerotic animals increased with time. CONCLUSIONS: This study suggests that a close relationship exists between prolonged atherosclerotic occlusion of major penile arteries and the development of corporal veno-occlusive dysfunction. Ischemia-induced corporal veno-occlusive dysfunction may be the result of alterations in corporal smooth muscle relaxation or changes in the structure and fibroelastic properties of erectile tissue. |
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Authors:
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K M Azadzoi; M B Siroky; I Goldstein |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of urology Volume: 155 ISSN: 0022-5347 ISO Abbreviation: J. Urol. Publication Date: 1996 May |
Date Detail:
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Created Date: 1996-06-26 Completed Date: 1996-06-26 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376374 Medline TA: J Urol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1795-800 Citation Subset: AIM; IM |
Affiliation:
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Department of Urology, Boston Veterans Affairs Medical Center, Massachusetts, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arteriosclerosis / complications* Erectile Dysfunction / physiopathology Hypercholesterolemia / complications Male Muscle Relaxation Muscle, Smooth / physiology Penis / blood supply*, physiology* Rabbits Vascular Diseases / etiology* |
| Grant Support | |
ID/Acronym/Agency:
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DK45087/DK/NIDDK NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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