Document Detail


Study of embryotoxicity of Perovskia abrotanoides, an adulterant in folk-medicine, during organogenesis in mice.
MedLine Citation:
PMID:  18337034     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM OF THE STUDY: Perovskia abrotanoides is a medicinal herb which traditionally has been used as a topical application to treat leishmaniasis in Iran. Due to similarities of the flowers of Perovskia abrotanoides and Echium species, it is added as an adulterant to Echium preparations in Iran. Echium flowers have been used in Iranian traditional medicine as an "anti-stress", tranquilizer, and energizer drink, fighting common cold and bronchitis particularly during pregnancy. In this study, the in vivo embryotoxicity of 0.125 and 0.25 g/kg of ethanolic and aqueous extracts of Perovskia abrotanoides during organogenesis in mice has been investigated. MATERIALS AND METHODS: Maternal body weights were recorded and pregnant females were observed daily throughout gestation. After cesarean section, fetuses were weighed, lengthed and examined for gross external malformations. Others were fixed then stained with Alcian blue and Alizarin red to view any skeletal malformations. RESULTS: Our results indicated that this herb causes minimal maternal toxicity, while resorption, stillborn, fetal malformations including polydactyly, spina bifida, aglossia, tarsal extensor, gastroschisis, and numerous skeletal abnormalities were detected particularly in the ethanolic extract groups. Specific skeletal abnormalities based on type of extract were also observed. CONCLUSIONS: Since Perovskia abrotanoides is widely used in traditional medicine intentionally or inadvertently, it is advisable its use during pregnancy should be avoided and strict regulations are imposed to prevent its addition to commercial preparations of other herbal products.
Authors:
Seyed Adel Moallem; Mariam Niapour
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-02-03
Journal Detail:
Title:  Journal of ethnopharmacology     Volume:  117     ISSN:  0378-8741     ISO Abbreviation:  J Ethnopharmacol     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-31     Completed Date:  2008-07-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7903310     Medline TA:  J Ethnopharmacol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  108-14     Citation Subset:  IM    
Affiliation:
Department of Pharmacodynamy & Toxicology, School of Pharmacy, Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. moallem@mums.ac.ir
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MeSH Terms
Descriptor/Qualifier:
Abnormalities, Drug-Induced*
Animals
Bone and Bones / abnormalities
Drug Contamination*
Female
Fetus / drug effects*
Lamiaceae / toxicity*
Male
Medicine, Traditional*
Mice
Plant Extracts / toxicity
Chemical
Reg. No./Substance:
0/Plant Extracts

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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