Document Detail


Study on effect of peptide-conjugated near-infrared fluorescent quantum dots on the clone formation, proliferation, apoptosis, and tumorigenicity ability of human buccal squamous cell carcinoma cell line BcaCD885.
MedLine Citation:
PMID:  20957161     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Quantum dots (QDs) have shown great development potential in noninvasive imaging and monitoring of cancer cells in vivo because of their unique optical properties. However, the key issue of whether or not QDs-labeled cancer cells affect the proliferation, apoptosis and in vivo tumorigenicity ability has not been reported. The primary issue is if the results obtained from the noninvasive visualization of QDs-labeled tumors are scientific. Here, we applied peptide-linked near-conjugated fluorescent QDs to label human buccal squamous cell carcinoma cell line (BcaCD885). We performed in vivo tumorigenicity ability assays, tumorigenic cells proliferation, and apoptotic capability assays detected by flow cytometry and plate clone formation experiment, and found that peptide-linked near-conjugated fluorescent QDs labeling did not affect the growth, proliferation, apoptosis, and tumorigenicity ability of those cancer cells. Our study provides scientific foundation to support the application of near-infrared fluorescent QDs in noninvasive imaging and monitoring of cancer cells in vivo.
Authors:
Deping Sun; Kai Yang; Gang Zheng; Zhigang Li; Yuan Cao
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-08-09
Journal Detail:
Title:  International journal of nanomedicine     Volume:  5     ISSN:  1178-2013     ISO Abbreviation:  Int J Nanomedicine     Publication Date:  2010  
Date Detail:
Created Date:  2010-10-19     Completed Date:  2011-01-28     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  101263847     Medline TA:  Int J Nanomedicine     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  401-5     Citation Subset:  IM    
Affiliation:
Department of Oral and Maxillofacial Surgery, First Affiliated Hospital, Chongqing Medical University, Chongqing, China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis
Carcinoma, Squamous Cell / pathology*
Cell Line, Tumor
Cell Proliferation
Cheek
Female
Fluorescence
Humans
Infrared Rays
Mice
Mice, Inbred BALB C
Mice, Nude
Mouth Neoplasms / pathology*
Nanomedicine
Neoplasm Transplantation
Peptides
Quantum Dots*
Transplantation, Heterologous
Tumor Stem Cell Assay
Chemical
Reg. No./Substance:
0/Peptides
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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