Document Detail


Study of the effect of the administration of Cd(II), cysteine, methionine, and Cd(II) together with cysteine or methionine on the conversion of xanthine dehydrogenase into xanthine oxidase.
MedLine Citation:
PMID:  10999428     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cadmium is known as to be a potent pulmonary carcinogen to human beings and to induce prostate tumor. The sequestration of cadmium, an extremely toxic element to living cells, which is performed by biological ligands such as amino acids, peptides, proteins or enzymes is important to minimize its participation in such deleterious processes. The synthesis of metallothionein is induced by a wide range of metals, in which cadmium is a particularly potent inducer. This protein is usually associated with cadmium exposure in man. Because metallothioneins may act as a detoxification agent for cadmium and chelation involves sulfur donor atoms, we administered only cadmium, cysteine, or methionine to rats and also each of these S-amino acids together with cadmium and measured the production of superoxide radicals derived from the conversion of xanthine dehydrogenase to xanthine oxidase. It could be seen in this work that the presence of cadmium enhances this conversion. However, its inoculation with cysteine or methionine almost completely diminishes this effect and this can be the result of the fact that these amino acids complex Cd(II). Thus, these compounds can be a model of the action of metallothionein, removing cadmium from circulation and preventing its deleterious effect.
Authors:
A C Esteves; J Felcman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biological trace element research     Volume:  76     ISSN:  0163-4984     ISO Abbreviation:  Biol Trace Elem Res     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-12-26     Completed Date:  2001-01-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7911509     Medline TA:  Biol Trace Elem Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  19-30     Citation Subset:  IM    
Affiliation:
Department of Chemistry, Pontifícia Universidade Católica do Rio de Janeiro, Rio de Janeiro, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cadmium / pharmacology*
Cysteine / pharmacology*
Free Radicals
Male
Methionine / pharmacology*
Rats
Rats, Wistar
Superoxides
Time Factors
Xanthine Dehydrogenase / metabolism*
Xanthine Oxidase / metabolism*
Chemical
Reg. No./Substance:
0/Free Radicals; 11062-77-4/Superoxides; 52-90-4/Cysteine; 63-68-3/Methionine; 7440-43-9/Cadmium; EC 1.17.1.4/Xanthine Dehydrogenase; EC 1.17.3.2/Xanthine Oxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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