| Study on the effect of T-2 toxin combined with low nutrition diet on rat epiphyseal plate growth and development. | |
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MedLine Citation:
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PMID: 20169345 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study was to observe early lesions of rat epiphyseal plates and metaphysis caused by T-2 toxin and T-2 toxin combined with a low nutrition diet to determine possible pathogenic factors of Kashin-Beck disease (KBD). Ninety Wistar rats were divided into three groups. Group A was fed with a normal diet as control; group B was fed with a normal diet and T-2 toxin; and group C was fed with a low nutrition diet and T-2 toxin. The left knee specimens were collected, fixed in formaldehyde solution, stained by hematoxylin and eosin and Masson. After two weeks, the epiphyseal plate showed necrosis of chondrocytes in groups B and C. After four weeks, more obvious chondrocyte necrosis appeared. The positive rate of Lamellar necrosis in group C was significantly higher than that in groups B and A (P < 0.01). Metaphyseal trabecular bone showed sparse disorder and disruption in group C. T-2 toxin combined with a low nutrition diet could lead to more serious chondrocyte necrosis in the epiphyseal plate and disturb metaphyseal trabecular bone formation. |
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Authors:
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Yun-fen Yao; Peng-de Kang; Xing-bo Li; Jing Yang; Bing Shen; Zong-ke Zhou; Fu-xing Pei |
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Publication Detail:
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Type: Journal Article Date: 2010-02-19 |
Journal Detail:
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Title: International orthopaedics Volume: 34 ISSN: 1432-5195 ISO Abbreviation: Int Orthop Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-10 Completed Date: 2011-03-10 Revised Date: 2011-12-21 |
Medline Journal Info:
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Nlm Unique ID: 7705431 Medline TA: Int Orthop Country: Germany |
Other Details:
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Languages: eng Pagination: 1351-6 Citation Subset: IM |
Affiliation:
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Orthopedic Department, West China Hospital, Sichuan University, Chengdu, People's Republic of China. bb_yaoyunfeng@126.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animal Nutritional Physiological Phenomena Animals Bone Development / drug effects* Chondrocytes / drug effects, pathology Diet / adverse effects* Epiphyses / drug effects* Female Growth Plate / drug effects* Hindlimb Male Necrosis / chemically induced Nutrition Disorders* Rats Rats, Wistar T-2 Toxin / toxicity* |
| Chemical | |
Reg. No./Substance:
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21259-20-1/T-2 Toxin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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