Document Detail

Study on the developmental toxicity of combined artesunate and mefloquine antimalarial drugs on rats.
MedLine Citation:
PMID:  23069110     Owner:  NLM     Status:  Publisher    
Antimalarial drug combinations containing artemisinins (ACTs) have become first choice therapies for P. falciparum malaria. Data on safety of ACTs in pregnancy are limited and no previous study has been conducted on the developmental toxicity of artesunate-mefloquine combinations on the first trimester of gestation. To evaluate the developmental toxicity of an artesunate/mefloquine combination, pregnant rats were treated orally with artesunate (15 and 40mg/kg bwt/day), mefloquine (30 and 80mg/kg bwt/day) and artesunate/mefloquine (15/30 and 40/80mg/kg bwt/day) on gestation days 9-11. Dams were C-sectioned on day 20, and their uteri and fetuses removed and examined for soft tissue and skeleton abnormalities. Artesunate increased embryolethality and the incidence of limb long bone malformations on the absence of overt maternal toxicity. Mefloquine (80mg/kg bwt/day) was maternally toxic and enhanced fetal variations. Combination of artesunate and mefloquine did not enhance their toxicity compared to the toxicity observed after its separate administration. Embryotoxicity of artesunate was apparently attenuated when it is co-administered with mefloquine.
Ana Cláudia Boareto; Juliane Centeno Muller; Samanta Luiza de Araujo; Ana Carolina Lourenço; Emerson Botelho Lourenço; Caroline Gomes; Bruna Minatovicz; Natália Lombardi; Francisco Roma Paumgartten; Paulo Roberto Dalsenter
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-12
Journal Detail:
Title:  Reproductive toxicology (Elmsford, N.Y.)     Volume:  -     ISSN:  1873-1708     ISO Abbreviation:  Reprod. Toxicol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8803591     Medline TA:  Reprod Toxicol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Inc.
Department of Pharmacology, Federal University of Paraná, P.O. Box 19031, CEP 81531-990 Curitiba, PR, Brazil. Electronic address:
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