Document Detail


Study design issues in evaluating immune biomarkers.
MedLine Citation:
PMID:  23380656     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: The dramatic increase in the number and type of immune biomarkers that can be measured, particularly those assessing immune activation, has led to numerous investigations in HIV-infected individuals to explore pathogenesis and to assess therapeutic interventions that aim to attenuate immune activation. An overview is provided on study designs and related statistical and operational issues relevant to these investigations.
RECENT FINDINGS: Cohort studies and nested case-control studies within these cohorts have identified multiple biomarkers that are associated with an increased risk of disease. Early-stage clinical trials of therapies to address these risks in HIV-infected individuals with viral suppression on antiretroviral therapy are a substantial focus of current HIV research.
SUMMARY: Appropriate study design is essential in biomarker research.
Authors:
Ronald J Bosch; Xinyan Zhang; Netanya G Sandler
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current opinion in HIV and AIDS     Volume:  8     ISSN:  1746-6318     ISO Abbreviation:  Curr Opin HIV AIDS     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-05     Completed Date:  2013-07-22     Revised Date:  2014-03-06    
Medline Journal Info:
Nlm Unique ID:  101264945     Medline TA:  Curr Opin HIV AIDS     Country:  United States    
Other Details:
Languages:  eng     Pagination:  147-54     Citation Subset:  IM; X    
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MeSH Terms
Descriptor/Qualifier:
Biological Markers*
Biomedical Research / methods*
HIV / immunology*
HIV Infections / immunology*
Humans
Monitoring, Immunologic / methods
Research Design*
Grant Support
ID/Acronym/Agency:
AI-68634/AI/NIAID NIH HHS; AI-68636/AI/NIAID NIH HHS; AI-76174/AI/NIAID NIH HHS; P01 AI074415/AI/NIAID NIH HHS; P01 AI076174/AI/NIAID NIH HHS; P01-AI074415/AI/NIAID NIH HHS; U01 AI068634/AI/NIAID NIH HHS; U01 AI068636/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers
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