| Study design issues in evaluating immune biomarkers. | |
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MedLine Citation:
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PMID: 23380656 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: The dramatic increase in the number and type of immune biomarkers that can be measured, particularly those assessing immune activation, has led to numerous investigations in HIV-infected individuals to explore pathogenesis and to assess therapeutic interventions that aim to attenuate immune activation. An overview is provided on study designs and related statistical and operational issues relevant to these investigations. RECENT FINDINGS: Cohort studies and nested case-control studies within these cohorts have identified multiple biomarkers that are associated with an increased risk of disease. Early-stage clinical trials of therapies to address these risks in HIV-infected individuals with viral suppression on antiretroviral therapy are a substantial focus of current HIV research. SUMMARY: Appropriate study design is essential in biomarker research. |
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Authors:
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Ronald J Bosch; Xinyan Zhang; Netanya G Sandler |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Current opinion in HIV and AIDS Volume: 8 ISSN: 1746-6318 ISO Abbreviation: Curr Opin HIV AIDS Publication Date: 2013 Mar |
Date Detail:
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Created Date: 2013-02-05 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101264945 Medline TA: Curr Opin HIV AIDS Country: United States |
Other Details:
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Languages: eng Pagination: 147-54 Citation Subset: IM; X |
Affiliation:
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aCenter for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, Massachusetts bHuman Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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