Document Detail


A study of cytokines in tuberculous meningitis: clinical and MRI correlation.
MedLine Citation:
PMID:  20691761     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There is paucity of studies on cytokines in tuberculous meningitis (TBM) and their relation with clinical and radiological changes; therefore this study was undertaken. 16 TBM patients diagnosed on the basis of clinical, CSF and radiological criteria were included. They were subjected to TNF-alpha, IL-6, IL-8, IL-10, IL-1beta, and IL-12p70 estimation in CSF. The cytokine levels were also estimated in 10 controls. Initial clinical examination, stage of TBM and MRI findings (infarct, hydrocephalus, tuberculoma and exudates) were recorded. The patients were treated with 4 drugs antitubercular (RHZE) therapy and after 3 months clinical examination, cytokine levels, and radiological studies were repeated. Outcome was defined by Barthel index score at 3 months into poor, partial and complete recovery. The patient's age ranged between 10 and 50 years, 5 were females. At 3 months, all the patients were clinically followed up and 14 underwent repeat MRI. 10 patients improved, 1 remained stable and 5 deteriorated. There was worsening with respect to tuberculoma in 3, infarction in 2 and exudate in 1 patient. TNF-alpha was expressed in 32% patients, IL-6, IL-10, IL-1beta and IL-8 were significantly expressed in patients and declined after 3 months following treatment. The cytokine levels did not correlate with stage of meningitis, outcome and radiological deterioration or improvement.
Authors:
Usha Kant Misra; Jayantee Kalita; Ruchi Srivastava; Pradeep P Nair; Manoj Kumar Mishra; Anirban Basu
Publication Detail:
Type:  Journal Article     Date:  2010-08-05
Journal Detail:
Title:  Neuroscience letters     Volume:  483     ISSN:  1872-7972     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-08-30     Completed Date:  2010-12-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  6-10     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Department of Neurology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareily Road, Lucknow 226014, India. drukmisra@rediffmail.com
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Antitubercular Agents / therapeutic use
Brain / pathology*
Child
Cytokines / cerebrospinal fluid*
Disease Progression
Enzyme-Linked Immunosorbent Assay
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Statistics, Nonparametric
Treatment Outcome
Tuberculosis, Meningeal / cerebrospinal fluid*,  drug therapy,  pathology*
Chemical
Reg. No./Substance:
0/Antitubercular Agents; 0/Cytokines

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