Document Detail


Study of cerebral aneurysms in a modified rat model: From real-time imaging to histological analysis.
MedLine Citation:
PMID:  25443088     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Cerebral aneurysm (CA) is a life-threatening condition with a pathogenesis that remains unclear. Previous hypotheses have primarily been based on in vitro examinations of animal models. Therefore, we attempted to observe CA in living rats and to establish a multi-level evaluation system. The rat model was produced by deoxycorticosterone-acetate (DOCA; Sigma Aldrich, St. Louis, MO, USA) induced hypertension and a single injection of elastase into the basal cistern. The animals were assessed 35days later. At the endpoint, we induced well-developed CA in 41.7% of the surviving rats. Using synchrotron radiation angiography (SRA), we observed the experimental aneurysms and their surrounding arteries dynamically in the living model. Further anatomical and histological analyses demonstrated the typical degenerative changes of the mural structure and a major infiltration of macrophages into the aneurysmal wall. In conclusion, we visualised well-developed experimental CA in living rats using SRA and demonstrated the associated degenerative histological changes and macrophage involvement; thus, we have provided an effective model for the study of dynamic multi-level changes associated with CA in a rat model.
Authors:
Jingjing Zhao; Xiaojie Lin; Chuan He; Guo-Yuan Yang; Feng Ling
Related Documents :
16790028 - Age-related effects of the neuromodulator d-serine on neurotransmission and synaptic po...
8997358 - Age-related changes in the responsiveness of apolipoprotein a1 to thyroid hormone.
6428498 - Influence of age, sex, pregnancy and protein-calorie malnutrition on the pharmacokineti...
21069158 - Biodistribution and long-term fate of silver nanoparticles functionalized with bovine s...
25445298 - Safety assessment of essential oil from minthostachys verticillata (griseb.) epling (pe...
2368928 - Ultrastructure of the pituitary intermediate lobe in aging rats.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-17
Journal Detail:
Title:  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia     Volume:  -     ISSN:  1532-2653     ISO Abbreviation:  J Clin Neurosci     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-12-2     Completed Date:  -     Revised Date:  2014-12-3    
Medline Journal Info:
Nlm Unique ID:  9433352     Medline TA:  J Clin Neurosci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Elsevier Ltd. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Clinical presentation and imaging characteristics of occult lung cancer associated ischemic stroke.
Next Document:  Clinical characteristics and long-term outcomes of moyamoya syndrome associated with neurofibromatos...