Document Detail

Study of the brainstem, particularly the arcuate nucleus, in sudden infant death syndrome (SIDS) and sudden intrauterine unexplained death (SIUD).
MedLine Citation:
PMID:  15075688     Owner:  NLM     Status:  MEDLINE    
Complete examination of the brainstem involves transverse serial 5-microm sections made throughout the entire brainstem. The number of serial sections varies from 360 in sudden intrauterine unexplained death (SIUD) to 600 in term fetuses to over 1400 sections in sudden infant death syndrome (SIDS) victims. The procedure is not applicable in all histopathological laboratories, owing to the need for additional technical personnel. The simplified procedure allows a remarkable reduction of the number of sections. The brainstem is divided into 3 blocks. The first, cranial block, extends from the border between the medulla oblongata and pons up to the upper pole of the olivary nucleus. The second, intermediate block, corresponding to the submedian area of the inferior olivary nucleus, has as reference point the obex and extends 2 to 3 mm above and below the obex itself. The third, caudal block, includes the lower pole of the inferior olivary nucleus and the lower adjacent area of the medulla oblongata. Examinations of the brainstems from 106 SIDS victims, 30 controls, and 51 stillborns underlined a remarkable variability, particularly of the arcuate nucleus. The simplified examination of the brainstem makes it possible to evaluate the structures, examining 3 specific levels, defined by morphologic reference points.
Luigi Matturri; Giulia Ottaviani; Graziella Alfonsi; Marina Crippa; Lino Rossi; Anna M Lavezzi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of forensic medicine and pathology     Volume:  25     ISSN:  0195-7910     ISO Abbreviation:  Am J Forensic Med Pathol     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-04-12     Completed Date:  2004-06-10     Revised Date:  2011-02-02    
Medline Journal Info:
Nlm Unique ID:  8108948     Medline TA:  Am J Forensic Med Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  44-8     Citation Subset:  IM    
Institute of Pathology, University of Milan, Italy.
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MeSH Terms
Arcuate Nucleus / pathology*
Autopsy / methods*
Brain Stem / pathology*
Case-Control Studies
Fetal Death / pathology*
Infant, Newborn
Neurons / pathology
Staining and Labeling / methods
Sudden Infant Death / pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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