Document Detail

Study of bovine trypanotolerance by whole transcriptome analysis.
MedLine Citation:
PMID:  19120177     Owner:  NLM     Status:  MEDLINE    
African trypanosomiases are parasitic diseases transmitted by tse-tse flies, considered as the main sanitary obstacle to animal production development in sub-Saharan Africa. However, if trypanosomiases have dramatic consequences on zebu (Bos indicus) populations, they have a weaker impact on the western African taurine (Bos taurus), which is known to be naturally tolerant to trypanosome infection. Mechanisms governing this trypanotolerant trait are still poorly understood, but today, recent postgenomic biotechnologies, such as the SAGE technique (serial analysis of gene expression) allow us to explore the full transcriptome. Twelve SAGE libraries were constructed from two trypanotolerant animals (N'Dama and Baoulé) and one susceptible species of cattle (the Sudanese zebu) during an experimental Trypanosoma congolense infection; 43,458 different tags were obtained at several particular points during the infection (before infection, at the maximum of parasitemia, the maximum of anemia, and at the end of the experiment after value normalization). Bioinformatics analyses highlighted some interesting gene variations with respect to the trypanotolerance status of the animal.
David Berthier; Isabelle Chantal; Sophie Thevenon; Hassane Sakande; Jean-Charles Maillard; Zakaria Bengaly; David Piquemal; Jacques Marti; Gerard Cuny
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  1149     ISSN:  1749-6632     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2009-01-05     Completed Date:  2009-01-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  71-6     Citation Subset:  IM    
CIRAD, UMR 17 Trypanosomes, F-34398, Montpellier, France.
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MeSH Terms
Cattle Diseases / genetics,  immunology*
RNA, Messenger / genetics*
Trypanosomiasis / genetics,  immunology*,  veterinary*
Reg. No./Substance:
0/RNA, Messenger

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