Document Detail

Study of blood lipids in 30 children with a malignant hematological disease or carcinoma.
MedLine Citation:
PMID:  6331857     Owner:  NLM     Status:  MEDLINE    
Levels of total lipids, cholesterol and triglycerides were followed in 30 children with malignant hematological diseases, or solid tumors; in addition, chylomicrons, VLDL, LDL and HDL were separated by electrophoresis on polyacrylamide gel. Nine of the 13 children with acute lymphoblastic leukaemia presented an increase of triglycerides and VLDL at time of diagnosis; all other parameters (cholesterol, HDL, LDL, chylomicrons) were normal. The lipid profile went back quickly to normal when hematological remission was obtained and remained stable throughout the course of the disease whatever the evolution might be. Five more patients in relapse were studied and did not present abnormalities. Similar results were obtained in 1/2 patients with acute myeloblastic leukaemia and in 3/5 patients with lymphoma. No lipid profile abnormality was observed in four patients with solid tumor and in one patient with histiocytosis X. The values of triglycerides and VLDL in pathological cases will be given. The endogenous nature of this disturbance is discussed as well as its relation with the rate of malignant lymphoid proliferation.
M C Favrot; C Dellamonica; G Souillet
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie     Volume:  38     ISSN:  0753-3322     ISO Abbreviation:  Biomed. Pharmacother.     Publication Date:  1984  
Date Detail:
Created Date:  1984-10-03     Completed Date:  1984-10-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8213295     Medline TA:  Biomed Pharmacother     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  55-9     Citation Subset:  IM    
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MeSH Terms
Apolipoproteins / blood
Apolipoproteins B
Child, Preschool
Hematologic Diseases / blood*
Histiocytosis, Langerhans-Cell / blood
Leukemia, Lymphoid / blood
Leukemia, Myeloid, Acute / blood
Lipids / blood*
Lymphoma / blood
Neoplasms / blood*
Phospholipids / blood
Time Factors
Triglycerides / blood
Reg. No./Substance:
0/Apolipoproteins; 0/Apolipoproteins B; 0/Lipids; 0/Phospholipids; 0/Triglycerides

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