| Study of the biological effects of theophylline on V79 cells: viability, membrane permeability, and metabolic cooperation. | |
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MedLine Citation:
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PMID: 1716177 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of theophylline, a specific inhibitor of phosphodiesterase, on gap junction-mediated intercellular communication between Chinese hamster V79 cells was examined. It was found that addition of theophylline to coculture of 6-thioguanine-resistant (TGr) and 6-thioguanine-sensitive (TGs) V79 cells significantly increased the recovery of TGr cells. This finding indicates an inhibition of metabolic cooperation of V79 cells by theophylline. Theophylline was tested at concentrations less than 0.3 mg/ml, which were neither cytotoxic (after short or continuous exposure) nor inhibited the synthesis of DNA, RNA, and proteins. At the tested concentrations, no change was found in the membrane permeability of cells. Theophylline did not increase the incorporation of glucose into the cells. |
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Authors:
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A Gabelova; D Slamenova; T Bohusova |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cell biology and toxicology Volume: 7 ISSN: 0742-2091 ISO Abbreviation: Cell Biol. Toxicol. Publication Date: 1991 Apr |
Date Detail:
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Created Date: 1991-10-15 Completed Date: 1991-10-15 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8506639 Medline TA: Cell Biol Toxicol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 183-92 Citation Subset: IM |
Affiliation:
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Department of Mutagenesis and Chemical Carcinogenesis, Cancer Research Institute of Slovak Academy of Sciences, Bratislava. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Communication / drug effects* Cell Division Cell Line Cell Membrane Permeability / drug effects* Cell Survival / drug effects* DNA / biosynthesis Deoxyglucose / metabolism Drug Resistance RNA / biosynthesis Tetradecanoylphorbol Acetate / pharmacology Theophylline / metabolism, pharmacology*, toxicity Thioguanine / pharmacology |
| Chemical | |
Reg. No./Substance:
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154-17-6/Deoxyglucose; 154-42-7/Thioguanine; 16561-29-8/Tetradecanoylphorbol Acetate; 58-55-9/Theophylline; 63231-63-0/RNA; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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