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A STUDY OF BARLOW'S DISEASE EXPERIMENTALLY PRODUCED IN FETAL AND NEW-BORN GUINEA PIGS.
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MedLine Citation:
PMID:  19867888     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
1. Pronounced cases of Barlow's disease may be produced in the fetus as early as ten to fifteen days after the commencement of dieting pregnant guinea pigs with oats and water. There are wide individual variations. The scorbutic changes in the skeleton are greatest in the earlier embryonic stages. The fetuses of that period, with practically no exceptions, die and show marked traces of impeded growth. 2. Fetuses from the later period of pregnancy are born alive, and apparently fully developed, with comparatively slight changes in the osseous system. 3. Even a short extension of the period of extra-uterine dieting on milk from scorbutic mothers and later on oats and water is sufficient to change the latent scurvy into a highly pronounced case. 4. The fetus cannot be kept alive longer than the adult animal, about twenty-eight days, either by intra-uterine dieting alone or by combined intra- and extra-uterine dieting. 5. The mothers show signs of disease at an early period, and are more severely attacked than non-pregnant animals. Death also occurs comparatively often in the first period of gestation.
Authors:
A Ingier
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of experimental medicine     Volume:  21     ISSN:  0022-1007     ISO Abbreviation:  J. Exp. Med.     Publication Date:  1915 Jun 
Date Detail:
Created Date:  2010-06-23     Completed Date:  2010-06-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985109R     Medline TA:  J Exp Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  525-38     Citation Subset:  -    
Affiliation:
Christiania, Norway.
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Full Text
Journal Information
Journal ID (nlm-ta): J Exp Med
ISSN: 0022-1007
ISSN: 1540-9538
Publisher: The Rockefeller University Press
Article Information
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Copyright © Copyright, 1915, by The Rockefeller Institute for Medical Research New York
Received Day: 4 Month: 2 Year: 1915
Print publication date: Day: 1 Month: 6 Year: 1915
Volume: 21 Issue: 6
First Page: 525 Last Page: 538
ID: 2125288
PubMed Id: 19867888

A STUDY OF BARLOW'S DISEASE EXPERIMENTALLY PRODUCED IN FETAL AND NEW-BORN GUINEA PIGS
Alexandra Ingier
Christiania, Norway.


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