Document Detail

Study of auditory function in patients with chronic obstructive pulmonary diseases.
MedLine Citation:
PMID:  16412595     Owner:  NLM     Status:  MEDLINE    
This study was designed to measure auditory function in patients with chronic obstructive pulmonary diseases (COPDs) who generally suffer from chronic hypoxemia. Control and COPD subject groups received a battery of tests to assess overall hearing sensitivity and peripheral (end-organ and eighth-nerve) and brain-stem auditory function, as well as blood-gas analysis. Results showed a statistically significant difference for all audiological measures between the control group and a COPD subgroup--the presumptive hypoxic subjects (partial oxygen tensions, PO2, <75 mm Hg). Correlation analyses of results from all subjects (regardless of PO2) also revealed significant covariance with PO2 for overall, RMS, amplitude of click-evoked otoacoustic emissions (RA), hearing threshold level, and auditory brain-stem response (ABR, I-V inter-peak latency). Chi2 or Fisher's exact tests were statistically significant for frequencies of cases classified according to a criterion PO2 of 70 mm Hg (putative critical O2 for completely normal auditory function) and either hearing thresholds falling below or RA values above 1.5 standard deviations of the control-group means, respectively. However, chi2 was not significant for a comparable criterion of ABR I-V IPL. In general, clinically significant hearing loss was uncommon in COPD patients, and the observed effects represented relatively small changes in the auditory measures examined. Still, overall, changes were in the direction of poorer function, and these results suggest physiologically significant impact of chronic hypoxemia and the need for further study to evaluate thoroughly this medical condition as a potential risk factor for audio-vestibular dysfunction.
Mona A el-Kady; John D Durrant; Somia Tawfik; Sarhan Abdel-Ghany; Abdel-Mateen Moussa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-01-18
Journal Detail:
Title:  Hearing research     Volume:  212     ISSN:  0378-5955     ISO Abbreviation:  Hear. Res.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-02-21     Completed Date:  2007-10-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7900445     Medline TA:  Hear Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  109-16     Citation Subset:  IM    
Department of Communication Science and Disorders, University of Pittsburgh, United States.
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MeSH Terms
Anoxia / etiology,  physiopathology*
Audiometry, Evoked Response
Auditory Diseases, Central / etiology*,  physiopathology
Blood Gas Analysis
Case-Control Studies
Chi-Square Distribution
Evoked Potentials, Auditory, Brain Stem / physiology
Middle Aged
Otoacoustic Emissions, Spontaneous / physiology
Pulmonary Disease, Chronic Obstructive / complications,  physiopathology*
Vestibular Diseases / etiology*,  physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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