| [Study on the association between 5,10-methylenetrahydrofolate reductase C677T polymorphism and acute lymphoblastic leukemia risk: a Meta-analysis]. | |
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MedLine Citation:
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PMID: 22333090 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the association between polymorphism of 5,10-methylenetrahydrofolate reductase C677T and risk of acute lymphoblastic leukemia (ALL). METHODS: Electronic search strategy was carried out among the databases from home and abroad to collect qualified research papers, according to the inclusion and exclusion criteria. Data on case-control studies on association between MTHFR C677T polymorphism and susceptibility to ALL were colleted and analyzed by models of TT vs. CC + CT or TT vs. CC through Meta-analysis. Stratified analysis was carried out according to different age groups (children or adult). RESULTS: In systematical analysis, the pooled odds ratios of MTHFR C677T genetype TT vs. CC + CT or TT vs. CC were 0.87 (0.69 - 1.09) and 0.82 (0.63 - 1.06) respectively; in children's group, the pooled odds ratios of MTHFR C677T genetype TT vs. CC + CT or TT vs. CC were 0.92 (0.79 - 1.08), 0.88 (0.75 - 1.05) while in adult group, the pooled odds ratios of MTHFR C677T genetype TT vs. CC + CT or TT vs. CC were 0.45 (0.26 - 0.77), and 0.41 (0.22 - 0.72) respectively. CONCLUSION: The MTHFR gene 677T variant might not be associated with the risk of children's ALL but might be associated with a reduced risk on adult's ALL. |
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Authors:
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Xiao-Lei Li; Feng Yu; Yong Zhang; Jin-Chun Qiu; Si-Ting Liu; Qing-Chuan Liao |
Publication Detail:
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Type: English Abstract; Journal Article |
Journal Detail:
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Title: Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi Volume: 32 ISSN: 0254-6450 ISO Abbreviation: Zhonghua Liu Xing Bing Xue Za Zhi Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2012-02-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8208604 Medline TA: Zhonghua Liu Xing Bing Xue Za Zhi Country: China |
Other Details:
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Languages: chi Pagination: 1030-6 Citation Subset: IM |
Affiliation:
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Department of Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, China. |
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Descriptor/Qualifier:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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