Document Detail

Study of ascorbate status in murine and human leukaemias.
MedLine Citation:
PMID:  3855878     Owner:  NLM     Status:  MEDLINE    
Since mice can synthesize ascorbic acid but man cannot, the ascorbate status in murine and human leukaemia was compared. The decline in plasma ascorbate concentration in both cases indicates that vitamin C deficiency occurs in malignancy. Analysis of tissue ascorbate values in mice also indicated that an enhanced rate of utilization of this vitamin occurs during malignancy, as does an increased rate of excretion, and both events may be responsible for vitamin C deficiency. The hepatic ascorbate values suggest an endeavour by the animals to compensate for the loss through increased synthesis and storage of the vitamin, at least in the early stages of the disease.
J Bhattacharjee; A S Chakraborty; N K Sarkar; A Basu; S Mitra
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of comparative pathology     Volume:  95     ISSN:  0021-9975     ISO Abbreviation:  J. Comp. Pathol.     Publication Date:  1985 Jan 
Date Detail:
Created Date:  1985-04-17     Completed Date:  1985-04-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0102444     Medline TA:  J Comp Pathol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  87-91     Citation Subset:  IM    
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MeSH Terms
Ascorbic Acid / blood,  metabolism*,  urine
Ascorbic Acid Deficiency / etiology
Kidney / metabolism
Leukemia, Experimental / blood,  complications,  metabolism*
Leukemia, Lymphoid / blood,  complications,  metabolism*
Leukemia, Myeloid / blood,  complications,  metabolism*
Liver / metabolism
Spleen / metabolism
Tissue Distribution
Reg. No./Substance:
50-81-7/Ascorbic Acid

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