| Study of alpha-lipoic acid penetration in the human aqueous after topical administration. | |
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MedLine Citation:
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PMID: 20456443 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To determine the concentration of alpha-lipoic acid in the aqueous and investigate if its topical instillation can increase quantities. METHODS: A total of 70 patients selected to undergo cataract surgery were randomly divided into two groups. Group 1 was used as a control group; for the patients in Group 2, a single instillation of alpha-lipoic acid eye drops (1%) was administered. Immediately before surgery, an aliquot of 40-120 microL of aqueous was aspirated. The individual aspirations were combined to constitute pools representing time intervals with respect to administration. The levels of alpha-lipoic acid in the aqueous were measured using gas chromatography/mass spectrometry. RESULTS: Pool 0 was created by combining the samples of aqueous obtained from the patients in Group 1, the control group; and the level of alpha-lipoic acid was 27.5 + 2.6 ng/mL. In the other pools, the time interval between the administration of the eye drops and sampling was, respectively, 23 min, 53 min, 72 min, 93 min and 114 min; and the level of alpha-lipoic acid was 33.0 + 10.8 ng/mL, 52.0 + 2.5 ng/mL, 86.7 + 2.5 ng/mL, 91.2 + 2.5 ng/mL and 80.3 + 2.5 ng/mL. CONCLUSION: Our study demonstrates the presence of alpha-lipoic acid in the aqueous and indicates that its concentration increases after it is administered in the form of eye drops, reaching maximum values after around 93 min. The concentrations that are achieved in the anterior chamber allow us to theorize the possibility of exploiting the antioxidant properties of alpha-lipoic acid. |
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Authors:
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Carlo Cagini; Arianna Leontiadis; Maria A Ricci; Anna Bartolini; Annalisa Dragoni; Roberto M Pellegrino |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Validation Studies Date: 2010-04-29 |
Journal Detail:
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Title: Clinical & experimental ophthalmology Volume: 38 ISSN: 1442-9071 ISO Abbreviation: Clin. Experiment. Ophthalmol. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-13 Completed Date: 2010-10-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100896531 Medline TA: Clin Experiment Ophthalmol Country: Australia |
Other Details:
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Languages: eng Pagination: 572-6 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, University of Perugia, Perugia, Italy. carlocagini@hotmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Aged Aged, 80 and over Antioxidants / administration & dosage, pharmacokinetics* Aqueous Humor / metabolism* Calibration Cornea / metabolism Female Gas Chromatography-Mass Spectrometry Humans Male Middle Aged Ophthalmic Solutions / administration & dosage, pharmacokinetics* Thioctic Acid / administration & dosage, pharmacokinetics* |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Ophthalmic Solutions; 62-46-4/Thioctic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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