| Study on the absorption and protein binding of carbaryl, dieldrin and paraquat in rats fed on protein diet. | |
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MedLine Citation:
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PMID: 6790724 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Carbaryl was well absorbed from the small intestine of rats. In the cytosol fraction of intestinal mucosa, it was bound to a smallmolecular component (M. W. 2,200 daltons). In serum, carbaryl was bound mainly to albumin and partly to globulins. Dieldrin was slowly absorbed from small intestine. The peak of dieldrin concentration in blood was observed 2.5 hr after the administration. Binding of dieldrin to mucosal protein in cytosol was not detectable. In serum, dieldrin was bound to lipoproteins, globulins and partly to albumin. Absorption of paraquat from the small intestine was more rapid than that of dieldrin in situ study. However, in vivo study, the absorption of paraquat was the lowest among these three chemicals. In the cytosol fraction of intestinal mucosa, paraquat was bound to a small-molecular component (M. W. 3,100 daltons). In serum, it was present in unbound fraction. In the comparative studies with protein diets, absorption of paraquat from small intestine in situ was higher in low protein diet rats than that in high protein diet rats. However, difference in absorption in vitro and in histopathological study was not noted between low protein diet rats and high protein diet rats. |
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Authors:
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R Tanaka; S Fujisawa; K Nakai |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of toxicological sciences Volume: 6 ISSN: 0388-1350 ISO Abbreviation: J Toxicol Sci Publication Date: 1981 Feb |
Date Detail:
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Created Date: 1981-10-14 Completed Date: 1981-10-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7805798 Medline TA: J Toxicol Sci Country: JAPAN |
Other Details:
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Languages: eng Pagination: 1-11 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bile / metabolism Carbaryl / metabolism* Dieldrin / metabolism Diet Dietary Proteins / pharmacology* Intestinal Absorption / drug effects Male Paraquat / metabolism* Protein Binding / drug effects Rats Subcellular Fractions / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Dietary Proteins; 4685-14-7/Paraquat; 60-57-1/Dieldrin; 63-25-2/Carbaryl |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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