Document Detail


Study of thrombophilia in recurrent pregnancy loss.
MedLine Citation:
PMID:  24082554     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Recently, it has been found that women who have thrombophilia have increased risk of fetal loss. This study was designed to corroborate the association of elevated factor VIII level, protein C and protein S deficiencies, and the presence of LAC in women with recurrent pregnancy loss.
MATERIALS AND METHODS: 53 patients with history of two or more pregnancy losses and 47 healthy age-matched subjects with no history of pregnancy loss and who have delivered at least one term infant without any complication were enrolled into the study.
RESULTS: Thrombophilic defect was present in 64.15 % of patients of study group. Protein S deficiency (50.94 %) was the most common thrombophilic defect observed. Spontaneous abortion (SA), preterm birth (PTB), and intrauterine growth retardation (IUGR) were the most important pregnancy complications observed. The strongest associations of pregnancy complications were observed with protein S deficiency (87.5 %) and with elevated factor VIII (66.66 %) level.
CONCLUSION: This study observed strong association of thrombophilia with unexplained recurrent pregnancy loss.
Authors:
Jayasree Hansda; Joydeb Roychowdhury
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Publication Detail:
Type:  Journal Article     Date:  2012-10-03
Journal Detail:
Title:  Journal of obstetrics and gynaecology of India     Volume:  62     ISSN:  0971-9202     ISO Abbreviation:  J Obstet Gynaecol India     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2013-10-01     Completed Date:  2013-10-01     Revised Date:  2013-10-17    
Medline Journal Info:
Nlm Unique ID:  0374763     Medline TA:  J Obstet Gynaecol India     Country:  India    
Other Details:
Languages:  eng     Pagination:  536-40     Citation Subset:  -    
Affiliation:
NRS Medical College, Kolkata, India ; C/O-Sri R C Hansda, 2/2 Krittibas Road (South), B-Zone, Durgapur, Burdwan, 713205 WB Kolkata, India.
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