Document Detail

Study of the potential of amphiphilic conetworks based on poly(2-ethyl-2-oxazoline) as new platforms for delivery of drugs with limited solubility.
MedLine Citation:
PMID:  23325383     Owner:  NLM     Status:  MEDLINE    
Thermoresponsive amphiphilic conetworks comprising poly(2-ethyl-2-oxazoline) (PEtOx), 2-hydroxyethyl methacrylate, and 2-hydroxypropyl acrylate segments have been studied as new platforms for delivery of drug with limited solubility. Series of conetworks of varied composition were synthesized and swelling kinetics in aqueous media and ethanol were followed. The platforms were loaded with the hydrophobic drug ibuprofen by swelling in its ethanol solution. The structure and properties of the drug carriers were investigated by scanning electron microscopy and differential scanning calorimetry. The release kinetics profiles of ibuprofen from the studied platform were established. The investigation proved the feasibility of the PEtOx-based amphiphilic conetworks as highly effective platforms for sustained ibuprofen delivery.
Bistra Kostova; Krasimira Ivanova-Mileva; Dimitar Rachev; Darinka Christova
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-01-17
Journal Detail:
Title:  AAPS PharmSciTech     Volume:  14     ISSN:  1530-9932     ISO Abbreviation:  AAPS PharmSciTech     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-26     Completed Date:  2013-08-12     Revised Date:  2014-01-23    
Medline Journal Info:
Nlm Unique ID:  100960111     Medline TA:  AAPS PharmSciTech     Country:  United States    
Other Details:
Languages:  eng     Pagination:  352-9     Citation Subset:  IM    
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MeSH Terms
Calorimetry, Differential Scanning
Drug Carriers*
Microscopy, Electron, Scanning
Polyamines / chemistry*
Reg. No./Substance:
0/Drug Carriers; 0/Polyamines; 0/poly(2-ethyl-2-oxazoline)

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