Document Detail

Study of HLA-A, B, C, DR, DQ profile of patients with established rheumatic heart disease in Kashmir.
MedLine Citation:
PMID:  9231545     Owner:  NLM     Status:  MEDLINE    
This study included 54 unselected patients with rheumatic heart disease (RHD) with or without history of rheumatic fever and 224 control subjects, all Kashmiris. HLA-A19 was increased in 42.59 percent of patient population as against 23.66 percent of controls, with a relative risk of 2.39. HLA-DR4 was positive in 56 percent of patients as against 31.69 percent in controls with a relative risk of 2.74. DQ3 was also present in 72 percent of patient population as against 50.7 percent of controls. These findings suggest a genetic predisposition to rheumatic fever/RHD. More family studies are warranted.
B A Wani
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian heart journal     Volume:  49     ISSN:  0019-4832     ISO Abbreviation:  Indian Heart J     Publication Date:    1997 Mar-Apr
Date Detail:
Created Date:  1997-09-04     Completed Date:  1997-09-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0374675     Medline TA:  Indian Heart J     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  152-4     Citation Subset:  IM    
Department of Medicine, Riyadh Medical Complex, KSA.
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MeSH Terms
Chronic Disease
Gene Frequency
HLA Antigens / immunology*
HLA-A Antigens / immunology
HLA-B Antigens / immunology
HLA-C Antigens / immunology
HLA-DQ Antigens / immunology
HLA-DR Antigens / immunology
Middle Aged
Rheumatic Heart Disease / ethnology,  immunology*
Reg. No./Substance:
0/HLA Antigens; 0/HLA-A Antigens; 0/HLA-B Antigens; 0/HLA-C Antigens; 0/HLA-DQ Antigens; 0/HLA-DR Antigens

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