| Study of HLA-A, B, C, DR, DQ profile of patients with established rheumatic heart disease in Kashmir. | |
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MedLine Citation:
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PMID: 9231545 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study included 54 unselected patients with rheumatic heart disease (RHD) with or without history of rheumatic fever and 224 control subjects, all Kashmiris. HLA-A19 was increased in 42.59 percent of patient population as against 23.66 percent of controls, with a relative risk of 2.39. HLA-DR4 was positive in 56 percent of patients as against 31.69 percent in controls with a relative risk of 2.74. DQ3 was also present in 72 percent of patient population as against 50.7 percent of controls. These findings suggest a genetic predisposition to rheumatic fever/RHD. More family studies are warranted. |
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Authors:
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B A Wani |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Indian heart journal Volume: 49 ISSN: 0019-4832 ISO Abbreviation: Indian Heart J Publication Date: 1997 Mar-Apr |
Date Detail:
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Created Date: 1997-09-04 Completed Date: 1997-09-04 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0374675 Medline TA: Indian Heart J Country: INDIA |
Other Details:
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Languages: eng Pagination: 152-4 Citation Subset: IM |
Affiliation:
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Department of Medicine, Riyadh Medical Complex, KSA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Chronic Disease Female Gene Frequency HLA Antigens / immunology* HLA-A Antigens / immunology HLA-B Antigens / immunology HLA-C Antigens / immunology HLA-DQ Antigens / immunology HLA-DR Antigens / immunology Humans India Male Middle Aged Rheumatic Heart Disease / ethnology, immunology* |
| Chemical | |
Reg. No./Substance:
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0/HLA Antigens; 0/HLA-A Antigens; 0/HLA-B Antigens; 0/HLA-C Antigens; 0/HLA-DQ Antigens; 0/HLA-DR Antigens |
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