Document Detail


Study of the expression of toll-like receptors in different histological types of colorectal polyps and their relationship with colorectal cancer.
MedLine Citation:
PMID:  22371291     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Dysregulation of toll-like receptors (TLR) signaling can result in chronic inflammatory and over-exuberant repair responses. The aim of this study was to investigate the expression and clinical relevance of TLR in colorectal polyps.
METHODS: The expression levels of six TLR were analyzed in 70 patients with different histological types of colorectal polyps, 38 of which developed colorectal carcinoma (CC). These analyses were performed by real-time polymerase chain reaction, western blot, and immunohistochemistry.
RESULTS: TLR9 expression was higher in hyperplastic or adenomatous polyps compared to other polyp types. Hyperplastic polyps also showed increased TLR7 levels compared to the other polyp types. TLR7 expression was lower in both hyperplastic and tubulovillous adenoma polyps from patients who developed CC. TLR9 expression was decreased in hyperplastic and villous polyps from patients who developed CC.
CONCLUSIONS: Our findings suggest a possible protective role of TLR expression against malignant transformation in the colorectal mucosa. TLR may represent a pathological marker of CC risk in colorectal polyps. The role of these factors in the pathology of colorectal polyps deserves further investigation.
Authors:
Noemí Eiró; Lucía González; Luis O González; Alejandro Andicoechea; María Fernández-Díaz; Antonio Altadill; Francisco J Vizoso
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-02-29
Journal Detail:
Title:  Journal of clinical immunology     Volume:  32     ISSN:  1573-2592     ISO Abbreviation:  J. Clin. Immunol.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-04     Completed Date:  2013-01-22     Revised Date:  2013-02-06    
Medline Journal Info:
Nlm Unique ID:  8102137     Medline TA:  J Clin Immunol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  848-54     Citation Subset:  IM    
Affiliation:
Unidad de Investigación, Hospital de Jove, Avenida Eduardo Castro s/n, C.P. 33290, Gijón, Asturias, Spain.
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MeSH Terms
Descriptor/Qualifier:
Adenomatous Polyps / immunology
Colonic Polyps / immunology*
Colorectal Neoplasms / immunology*
Female
Humans
Male
Toll-Like Receptor 7 / genetics,  metabolism*
Toll-Like Receptor 9 / genetics,  metabolism*
Chemical
Reg. No./Substance:
0/TLR7 protein, human; 0/TLR9 protein, human; 0/Toll-Like Receptor 7; 0/Toll-Like Receptor 9
Comments/Corrections
Comment In:
J Clin Immunol. 2012 Dec;32(6):1421-2   [PMID:  22711010 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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