| Study of Convolvulus pluricaulis for antioxidant and anticonvulsant activity. | |
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MedLine Citation:
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PMID: 22280406 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Convolvulus pluricaulis Choisy is a perennial wild herb commonly found on sandy & rocky areas under xerophytic conditions in northern India. It is a reputed drug of ayurveda and reported to posses antioxidant, brain tonic, nervine tonic, laxative and has been used in anxiety, neurosis, epilepsy, insomnia, burning sensation, oedema and urinary disorders. In the present study, methanolic extract of whole plant of Convolvulus pluricaulis Choisy was evaluated for antioxidant activity by using 1, 1-diphenyl-2-picryl- hydrazyl (DPPH) free radical scavenging model and anticonvulsant activity by using maximal electroshock seizure model. In antioxidant activity, ascorbic acid was used as standard agent while results of anticonvulsant studies were compared with phenytoin. Results of antioxidant activity have demonstrated significant free radical scavenging effect for methanolic extract of Convolvulus pluricaulis Choisy. IC50 value of methanolic extract was observed as 41.00μg/ml as compared to 2.03μg/ml of ascorbic acid. Methanolic extract of C. pluricaulis was evaluated for anticonvulsant activity at 250, 500 and 1000mg/kg. Experimental results have shown that at the dose of 500 and 1000mg/kg, C. pluricaulis didn't abolish the hind limb extension, but reduced the mean recovery time from convulsion. |
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Authors:
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Sristi Verma; Reema Sinha; Puspendra Kumar; Faizal Amin; Jainendra Jain; Shivani Tanwar |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-25 |
Journal Detail:
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Title: Central nervous system agents in medicinal chemistry Volume: - ISSN: 1875-6166 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101269163 Medline TA: Cent Nerv Syst Agents Med Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Ram-Eesh Institute of Vocational and Technical Education, Plot No. 3, Knowledge Park- I, Kasna Road, Greater Noida, Gautam Budh Nagar-201310, Uttar Pradesh, India. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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