Document Detail


Study on the constituents of Mexican propolis and their cytotoxic activity against PANC-1 human pancreatic cancer cells.
MedLine Citation:
PMID:  20307087     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Three new flavonoids, (2R,3R)-3,5-dihydroxy-7-methoxyflavanone 3-(2-methyl)butyrate (1), (7''R)-8-[1-(4'-hydroxy-3'-methoxyphenyl)prop-2-en-1-yl]chrysin (2), and (7''R)-8-[1-(4'-hydroxy-3'-methoxyphenyl)prop-2-en-1-yl]galangin (3), together with 41 known compounds (4-44) were isolated from a methanolic extract of Mexican propolis. Compounds 2 and 3 are unique natural flavones containing a 1-phenylallyl moiety. The in vitro preferential cytotoxicity of all the isolates was evaluated against a PANC-1 human pancreatic cell line. Compound 3 displayed the most potent preferential cytotoxicity (PC(50) 4.6 microM) in the nutrient-deprived medium (NDM) and triggered apoptosis-like morphological changes in PANC-1 cells.
Authors:
Feng Li; Suresh Awale; Yasuhiro Tezuka; Hiroyasu Esumi; Shigetoshi Kadota
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of natural products     Volume:  73     ISSN:  1520-6025     ISO Abbreviation:  J. Nat. Prod.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-23     Completed Date:  2010-06-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7906882     Medline TA:  J Nat Prod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  623-7     Citation Subset:  IM    
Affiliation:
Institute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama 930-0194, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antineoplastic Agents / chemistry,  isolation & purification*,  pharmacology*
Apoptosis / physiology
Bees
Drug Screening Assays, Antitumor
Flavonoids / chemistry,  isolation & purification*,  pharmacology*
Humans
Mexico
Molecular Structure
Pancreatic Neoplasms / drug therapy
Propolis / chemistry*,  pharmacology*
Stereoisomerism
Chemical
Reg. No./Substance:
0/(2R,3R)-3,5-dihydroxy-7-methoxyflavanone 3-(2-methyl)butyrate; 0/(7''R)-8-(1-(4'-hydroxy-3'-methoxyphenyl)prop-2-en-1-yl)chrysin; 0/(7''R)-8-(1-(4'-hydroxy-3'-methoxyphenyl)prop-2-en-1-yl)galangin; 0/Antineoplastic Agents; 0/Flavonoids; 9009-62-5/Propolis

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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