Document Detail


Study of Chemical Ligation via 17-, 18- and 19-Membered Cyclic Transition States.
MedLine Citation:
PMID:  22974460     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Unprotected S-acylated cysteine isopeptides containing α-, β- or γ-amino acid units have been synthesized and their conversion to native hexapeptides by S- to the N- terminus ligations involving 17-, 18- and 19-membered cyclic transition states have been demonstrated both experimentally and computationally to be more favorable than intermolecular cross-ligations. © 2012 John Wiley & Sons A/S.
Authors:
Siva S Panda; Claudia El-Nachef; Kiran Bajaj; Abdulrahman O Al-Youbi; Alex Oliferenko; Alan R Katritzky
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-14
Journal Detail:
Title:  Chemical biology & drug design     Volume:  -     ISSN:  1747-0285     ISO Abbreviation:  Chem Biol Drug Des     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101262549     Medline TA:  Chem Biol Drug Des     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 John Wiley & Sons A/S.
Affiliation:
Center for Heterocyclic Compounds, University of Florida, Department of Chemistry, Gainesville, Florida 32611-7200, USA Chemistry Department, King Abdulaziz University, Jeddah, 21589 Saudi Arabia.
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