| Multicentric study on a topical compound with lymph-draining action in the treatment of the phlebostatic ulcer of the inferior limbs | |
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MedLine Citation:
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PMID: 20109380 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Phlebostatic sore of the lower limbs is a typical chronic venous insufficiency complication and is still a widely controversial issue in its treatment. The common therapies, in fact, are not yet standardized and they not show complete efficacy. Since 2005 to 2007 a multicentric clinical trial was conducted at the Plastic and Reconstructive Surgery of "Sapienza" University of Rome and at the Plastic and Reconstructive Surgery Department, University of Perugia, in order to evaluate the efficacy of the Idrastin lymph-draining cream in patients with phlebostatic sores of the lower limbs. This study enrolled on 80 patients, split into 2 homogeneous groups of 40 patients: group A was treated by only elastocompressive therapy, group B by elastocompressive therapy and Idrastin. Multicentric analysis has considered the following parameters: local pain, perilesional flogosis , granulation tissue, perilesional tissue tropism healing time. In the group B results highlighted: reduction of the local pain, stopped in 72 hours; flogosis decrease disappeared in one week; tissue granulation growth in one week; lesion healing in 4 weeks. These results pointed out statistically significance of the variables considered. In our opinion Idrastin compounds such as phytoessence of hops and Hedera helix, had contributed to analgesia; Aesculus hippocastanum, and Vitis vinifera and Ruscus aculeatus phytoessence showed anti-flogistic action; allantoin and Centella asiatica and jaluronic acid aided to sore healing. Idrastin gives an effective support to the treatment of the phlebostatic sores warrants a faster and more effective healing process, than to the wounds treated by only the elastocompressive therapy. |
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Authors:
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S Chiummariello; F De Gado; C Monarca; M Ruggiero; B Carlesimo; N Scuderi; C Alfano |
Publication Detail:
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Type: Controlled Clinical Trial; English Abstract; Journal Article; Multicenter Study |
Journal Detail:
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Title: Il Giornale di chirurgia Volume: 30 ISSN: 0391-9005 ISO Abbreviation: G Chir Publication Date: 2009 Nov-Dec |
Date Detail:
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Created Date: 2010-01-29 Completed Date: 2010-05-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9011768 Medline TA: G Chir Country: Italy |
Other Details:
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Languages: ita Pagination: 497-501 Citation Subset: IM |
Affiliation:
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Universit? degli Studi di Perugia, Cattedra di Chirurgia Plastica e Ricostruttiva. |
Vernacular Title:
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Studio multicentrico su un preparato topico ad azione linfodrenante nel trattamento dell'ulcera flebostatica degli arti inferiori. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Cutaneous Atrophy Combined Modality Therapy Debridement Dermatologic Agents / administration & dosage, therapeutic use* Diabetes Complications / drug therapy, surgery, therapy Edema / complications, drug therapy, therapy Female Humans Lymph / drug effects Male Middle Aged Ointments Phytotherapy* Plant Preparations / administration & dosage, therapeutic use* Pyoderma / complications Recurrence Saphenous Vein / surgery Stockings, Compression Varicose Ulcer / drug therapy*, pathology, surgery, therapy Wound Healing |
| Chemical | |
Reg. No./Substance:
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0/Dermatologic Agents; 0/Idrastin; 0/Ointments; 0/Plant Preparations |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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