Document Detail


Studies with tryptophan metabolites in vitro. Kynurenine metabolism in liver homogenates of normal and Schistosoma mansoni-infested mice.
MedLine Citation:
PMID:  6048805     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The conversion of kynurenine into kynurenic acid and anthranilic acid in both normal and Schistosoma mansoni-infested mouse liver was investigated. It was found that in the S. mansoni-infested mouse liver there is probably a deficiency of pyridoxal phosphate that resulted in an inhibition of kynurenine transaminase and a low production of kynurenic acid. Deoxypyridoxine and its phosphorylated derivative inhibited kynurenine transaminase in the normal liver in a pattern qualitatively similar to that observed with infested liver. The lowered concentration of pyridoxal phosphate in the infested liver is discussed in view of the possibility of two combined mechanisms: (a) an antimetabolite being secreted by the infesting worms or present in its eggs that partially inhibited the phosphorylation of pyridoxal, and (b) concentration of pyridoxal phosphate by the worms, resulting in a lowered concentration of the cofactor in the host tissue.
Authors:
M S Amer; M H Abdel-Daim; G A Abdel-Tawab
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Biochemical journal     Volume:  104     ISSN:  0264-6021     ISO Abbreviation:  Biochem. J.     Publication Date:  1967 Aug 
Date Detail:
Created Date:  1967-12-13     Completed Date:  1967-12-13     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  656-62     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Anthranilic Acids / metabolism
Kinetics
Kynurenine / metabolism*
Liver / metabolism*
Mice
Perfusion
Pyridoxal Phosphate / metabolism
Pyridoxine / pharmacology
Schistosomiasis / metabolism*
Tryptophan / metabolism*
Chemical
Reg. No./Substance:
0/Anthranilic Acids; 343-65-7/Kynurenine; 54-47-7/Pyridoxal Phosphate; 65-23-6/Pyridoxine; 73-22-3/Tryptophan
Comments/Corrections

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