Document Detail

Studies with tryptophan metabolites in vitro. Kynurenine metabolism in liver homogenates of normal and Schistosoma mansoni-infested mice.
MedLine Citation:
PMID:  6048805     Owner:  NLM     Status:  MEDLINE    
The conversion of kynurenine into kynurenic acid and anthranilic acid in both normal and Schistosoma mansoni-infested mouse liver was investigated. It was found that in the S. mansoni-infested mouse liver there is probably a deficiency of pyridoxal phosphate that resulted in an inhibition of kynurenine transaminase and a low production of kynurenic acid. Deoxypyridoxine and its phosphorylated derivative inhibited kynurenine transaminase in the normal liver in a pattern qualitatively similar to that observed with infested liver. The lowered concentration of pyridoxal phosphate in the infested liver is discussed in view of the possibility of two combined mechanisms: (a) an antimetabolite being secreted by the infesting worms or present in its eggs that partially inhibited the phosphorylation of pyridoxal, and (b) concentration of pyridoxal phosphate by the worms, resulting in a lowered concentration of the cofactor in the host tissue.
M S Amer; M H Abdel-Daim; G A Abdel-Tawab
Related Documents :
2101085 - Saturated fatty acids with different chain lengths as ketogenic substrates in the rat l...
9114985 - Evidence for a covalently bound form of microcystin-lr in salmon liver and dungeness cr...
3789655 - Effects of feeding high-fat diets to rats: metabolism of erucic acid (c 22:1 n-9) in th...
14637195 - Glycyrrhetinic acid-induced permeability transition in rat liver mitochondria.
12963425 - Amino acid substitutions in pkr-eif2 phosphorylation homology domain (pephd) of hepatit...
17076095 - Expression and distribution of cd44 and hyaluronic acid in human vocal fold mucosa.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Biochemical journal     Volume:  104     ISSN:  0264-6021     ISO Abbreviation:  Biochem. J.     Publication Date:  1967 Aug 
Date Detail:
Created Date:  1967-12-13     Completed Date:  1967-12-13     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  656-62     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anthranilic Acids / metabolism
Kynurenine / metabolism*
Liver / metabolism*
Pyridoxal Phosphate / metabolism
Pyridoxine / pharmacology
Schistosomiasis / metabolism*
Tryptophan / metabolism*
Reg. No./Substance:
0/Anthranilic Acids; 343-65-7/Kynurenine; 54-47-7/Pyridoxal Phosphate; 65-23-6/Pyridoxine; 73-22-3/Tryptophan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The regulation of propionate oxidation in Prototheca zopfii.
Next Document:  A study of three enzymes acting on glucose in the lens of different species.