Document Detail

Studies with radioactive endotoxin. II. Clearance of 3H-labelled endotoxin from the blood of calves.
MedLine Citation:
PMID:  4279755     Owner:  NLM     Status:  MEDLINE    
The clearance of (3)H-labelled Pseudomonas endotoxin from the blood was studied in a nontolerant and in an endotoxin tolerant state. Calves were rendered tolerant to the toxic effects of the endotoxin by four daily intravenous injections of endotoxin at the dose rate of 5 microg/kg body weight. Clearance of (3)H-endotoxin from the blood of nontolerant calves occurred more slowly than did clearance of (51)Cr-endotoxin and was not significantly (P<0.05) affected by the development of tolerance. The lungs and liver were the major organs involved in the clearance of (3)H-endotoxin from the blood of calves. Leukocytes and erythrocytes, but not platelets, were shown to participate in endotoxin clearance in calves. (3)H(2)O, the control substance used in calves, was not concentrated within any particular organ but rapidly equilibrated with total body water and was slowly excreted.
M G Maxie; V E Valli; J H Lumsden
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Canadian journal of comparative medicine. Revue canadienne de médecine comparée     Volume:  38     ISSN:  0008-4050     ISO Abbreviation:  Can. J. Comp. Med.     Publication Date:  1974 Oct 
Date Detail:
Created Date:  1975-03-10     Completed Date:  1975-03-10     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0151747     Medline TA:  Can J Comp Med     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  367-82     Citation Subset:  IM    
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MeSH Terms
Blood Cell Count
Blood Platelets / analysis
Cattle / blood*
Cattle Diseases / blood
Cell Separation
Endotoxins / administration & dosage,  blood*,  metabolism
Feces / analysis
Fever / veterinary
Heart Rate
Injections, Intravenous
Isotope Labeling
Leukocyte Count
Leukocytes / analysis
Leukopenia / veterinary
Liver / metabolism
Lung / metabolism
Pseudomonas aeruginosa
Time Factors
Reg. No./Substance:
0/Endotoxins; 10028-17-8/Tritium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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