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STUDIES ON UROBILIN PHYSIOLOGY AND PATHOLOGY : VI. THE RELATION OF BILIARY INFECTIONS TO THE GENESIS AND EXCRETION OF UROBILIN.
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MedLine Citation:
PMID:  19869159     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Experimental infection of the intubated and previously sterile biliary tract of the dog with particles of the stools leads to a formation of urobilin from the bilirubin of the bile as it flows through the ducts. No urobilinuria occurs, however, unless temporary biliary obstruction is produced, or the liver parenchyma injured. Then urobilinuria develops, despite the fact that no bile is reaching the intestine and, by corollary, no urobilin being formed there. Cholangitic urobilinuria, as one may term the phenomenon just described, to distinguish it from the urobilinuria having origin in pigment absorbed from within the intestine, is far more pronounced in animals possessing a healthy gall bladder than in those with a pathological gall bladder or with one prevented from functioning by severance of the cystic duct. These facts suggest that there may be an active absorption of urobilin from the normal gall bladder. There can be no doubt that the pigment is absorbed from within the bile ducts. There is no evidence whatever to justify the belief that urobilin is ever formed through the action of liver parenchyma. There may conceivably be an intralobular formation of the pigment consequent upon the activity of bacteria within the liver tissue, though such a happening has yet to be demonstrated.
Authors:
P D McMaster; R Elman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of experimental medicine     Volume:  43     ISSN:  0022-1007     ISO Abbreviation:  J. Exp. Med.     Publication Date:  1926 May 
Date Detail:
Created Date:  2010-06-23     Completed Date:  2010-06-23     Revised Date:  2010-09-28    
Medline Journal Info:
Nlm Unique ID:  2985109R     Medline TA:  J Exp Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  753-83     Citation Subset:  -    
Affiliation:
Laboratories of The Rockefeller Institute for Medical Research.
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Full Text
Journal Information
Journal ID (nlm-ta): J Exp Med
ISSN: 0022-1007
ISSN: 1540-9538
Publisher: The Rockefeller University Press
Article Information
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Copyright © Copyright, 1926, by The Rockefeller Institute for Medical Research New York
Received Day: 17 Month: 3 Year: 1926
Print publication date: Day: 31 Month: 5 Year: 1926
Volume: 43 Issue: 6
First Page: 753 Last Page: 783
ID: 2131136
PubMed Id: 19869159

STUDIES ON UROBILIN PHYSIOLOGY AND PATHOLOGY : VI. THE RELATION OF BILIARY INFECTIONS TO THE GENESIS AND EXCRETION OF UROBILIN.
Philip D. McMaster
Robert Elman
From the Laboratories of The Rockefeller Institute for Medical Research.


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