| Studies of tyramine transfer and metabolism using an in vitro intestinal preparation. | |
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MedLine Citation:
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PMID: 8046612 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The duodenal transfer and metabolism of [3H]tyramine from sacs and perfused segments of rat intestine were determined. In sacs, a linear relationship between the steady-state transfer rate of total tritium and the initial mucosal tyramine concentration was observed, suggesting that the clearance is the same at different concentrations. In duodenal perfusions, there was no significant difference in the amount of total tritium removed between control and everted tissues, whether the flow was 0.2 or 2.0 mL/min. The percentage of [3H]tyramine extracted from the gut lumen depended on the flow rate. About 30-40% of the extracted drug was metabolized; this value decreased to 20% when the rats were pretreated with pargyline. The data support the idea that the transfer mechanism for tyramine is simple diffusion. |
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Authors:
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D M Tchercansky; C Acevedo; M C Rubio |
Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Journal of pharmaceutical sciences Volume: 83 ISSN: 0022-3549 ISO Abbreviation: J Pharm Sci Publication Date: 1994 Apr |
Date Detail:
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Created Date: 1994-08-30 Completed Date: 1994-08-30 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 2985195R Medline TA: J Pharm Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 549-52 Citation Subset: IM |
Affiliation:
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Cátedra de Farmacologia, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Argentina. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chemistry, Physical Diffusion Duodenum / drug effects, enzymology, metabolism Intestinal Absorption / drug effects Intestinal Mucosa / drug effects, enzymology, metabolism Intestines / drug effects, enzymology, metabolism* Male Monoamine Oxidase / metabolism Pargyline / pharmacology Perfusion Physicochemical Phenomena Rats Rats, Wistar Tyramine / metabolism, pharmacokinetics* |
| Chemical | |
Reg. No./Substance:
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51-67-2/Tyramine; 555-57-7/Pargyline; EC 1.4.3.4/Monoamine Oxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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