| Studies on the toxicity and antiviral activity of various polynucleotides. | |
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MedLine Citation:
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PMID: 4790587 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Various polynucleotides were examined for antiviral activity and toxicity in mice. Although the antiviral potency of the various interferon inducers varied, there was a concomitant variation in toxicity. This was reflected by a fivefold range in therapeutic ratio for the various compounds. In addition, no polynucleotide proved to be a more potent interferon inducer than polyinosinic.polycytidylic acid [(poly rI).(poly rC)]. Our results suggest that there may be intrinsic limitations to the development of polynucleotide interferon inducers having improved therapeutic ratios. |
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Authors:
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D R Black; F Eckstein; E DeClercq; T C Merigan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Antimicrobial agents and chemotherapy Volume: 3 ISSN: 0066-4804 ISO Abbreviation: Antimicrob. Agents Chemother. Publication Date: 1973 Feb |
Date Detail:
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Created Date: 1974-07-18 Completed Date: 1974-07-18 Revised Date: 2010-09-13 |
Medline Journal Info:
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Nlm Unique ID: 0315061 Medline TA: Antimicrob Agents Chemother Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 198-206 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antiviral Agents* Female Interferon Inducers* Mice Molecular Weight Poly I-C / pharmacology Polynucleotides / pharmacology*, toxicity |
| Chemical | |
Reg. No./Substance:
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0/Antiviral Agents; 0/Interferon Inducers; 0/Polynucleotides; 24939-03-5/Poly I-C |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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