| Studies on the toxicity of the antitumour agent N-methylformamide in mice. | |
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MedLine Citation:
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PMID: 3969688 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Aspects of the toxicology of N-methylformamide (NMF), an investigational antitumour agent, were studied in mice. After injection of NMF at its LD10 (800 mg/kg) dosage the total peripheral white blood cell and platelet counts were unchanged in BALB/c mice. A mild granulocytosis was seen in this strain after administration of the LD50 (2300 mg/kg) dosage. Plasma activity of the enzyme sorbitol dehydrogenase in BDF1 mice was markedly increased after either a single injection of not less than 800 mg/kg or a chronic treatment of not less than 400 mg/kg/day over 5 days indicating the drug to be hepatotoxic. Plasma activities of L-alanine and L-aspartate aminotransferases were also increased after the chronic treatment. Chronic administration of NMF was less hepatotoxic than single dose administration of the same total dose and also increased the antitumour efficacy of NMF against the M5076 sarcoma. These results indicate that the maximum therapeutic benefit of NMF might be obtained by the use of chronic schedules and that the drug is not myelosuppressive. |
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Authors:
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S P Langdon; D Chubb; A Gescher; J A Hickman; M F Stevens |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Toxicology Volume: 34 ISSN: 0300-483X ISO Abbreviation: Toxicology Publication Date: 1985 Feb |
Date Detail:
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Created Date: 1985-03-20 Completed Date: 1985-03-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0361055 Medline TA: Toxicology Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 173-83 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alanine Transaminase
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blood Animals Antineoplastic Agents Aspartate Aminotransferases / blood Cyclophosphamide / toxicity Formamides / therapeutic use, toxicity* Granulocytes / cytology L-Iditol 2-Dehydrogenase / blood Lethal Dose 50 Leukocyte Count Liver / drug effects Mice Mice, Inbred BALB C Platelet Count Sarcoma, Experimental / drug therapy |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Formamides; 123-39-7/methylformamide; 50-18-0/Cyclophosphamide; EC 1.1.1.14/L-Iditol 2-Dehydrogenase; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.6.1.2/Alanine Transaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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