Document Detail


Studies toward birth and early mammalian development in space.
MedLine Citation:
PMID:  15000095     Owner:  NASA     Status:  MEDLINE    
Abstract/OtherAbstract:
Sustaining life beyond Earth on either space stations or other planets will require a clear understanding of how the space environment affects key phases of mammalian reproduction and development. Pregnancy, parturition (birth) and the early development of offspring are complex processes essential for successful reproduction and the proliferation of mammalian species. While no mammal has yet undergone birth within the space environment, studies spanning the gravity continuum from 0- to 2-g are revealing startling insights into how reproduction and development may proceed under gravitational conditions deviating from those typically experienced on Earth. In this report, I review studies of pregnant Norway rats and their offspring flown in microgravity onboard the NASA Space Shuttle throughout the period corresponding to mid- to late gestation, and analogous studies of pregnant rats exposed to hypergravity (hg) onboard the NASA Ames Research Center 24-ft centrifuge. Studies of postnatal rats flown in space or exposed to centrifugation are reviewed. Although many important questions remain unanswered, the available data suggest that numerous aspects of pregnancy, birth and early mammalian development can proceed under altered gravity conditions.
Authors:
April E Ronca
Related Documents :
2364565 - Serum free 1,25-dihydroxyvitamin d and the free 1,25-dihydroxyvitamin d index during a ...
9579385 - Mobilization of lead from the skeleton during the postnatal period is larger than durin...
18321785 - Different physiological roles of serum leptin in the regulation of energy intake and th...
353925 - Immunocyte populations in the mammary gland of the rat at different stages of pregnancy...
15898935 - Characteristics of periodontal microflora in acute myocardial infarction.
19530005 - Alcohol and b1 vitamin deficiency-related stillbirths.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Advances in space research : the official journal of the Committee on Space Research (COSPAR)     Volume:  32     ISSN:  0273-1177     ISO Abbreviation:  Adv Space Res     Publication Date:  2003  
Date Detail:
Created Date:  2004-03-04     Completed Date:  2008-07-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9878935     Medline TA:  Adv Space Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1483-90     Citation Subset:  S    
Copyright Information:
Published by Elsevier Ltd on behalf of COSPAR.
Affiliation:
Life Sciences Division, NASA Ames Research Center, Moffett Field, CA 94035, USA. aronca@mail.arc.nasa.gov
Space Flight Mission:
Flight Experiment; STS-66 Shuttle Project; STS-70 Shuttle Project; manned; short duration
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn / growth & development
Behavior, Animal*
Centrifugation
Female
Fertilization
Hypergravity*
Maternal Behavior
Parturition
Pregnancy
Pregnancy, Animal*
Rats
Space Flight*
Weightlessness*
Grant Support
ID/Acronym/Agency:
NIMH 46485//NASA
Investigator
Investigator/Affiliation:
A E Ronca / NASA ARC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Adolescent and parent perspectives on ethical issues in youth drug use and suicide survey research.
Next Document:  Animal ethical evaluation: an observational study of Canadian IACUCs.