Document Detail

Studies on thromboplastic and fibrinolytic activities of valvular tissue in rheumatic valvular disease.
MedLine Citation:
PMID:  7367759     Owner:  NLM     Status:  MEDLINE    
While rheumatic valvular disease (RVD) is known to develop subsequent to rheumatic carditis, we examined whether in addition to the inflammatory and repair process, thromboplastic and fibrinolytic activities of the valvular tissue play a contributory role in the pathogenesis of RVD. Both activities were higher in resected valves from RVD cases than in the controls. Tissue thromboplastin was localized in the valvular endothelium and the subendothelial connective tissue. Tissue fibrinolytic activity was prevalent in the small blood vessels of RVD valves, while it was lower on the surface of RVD valves than in the controls. High thromboplastic and low fibrinolytic activity in the surface layer of RVD valves may accelerate the deposition of thrombi, thereby inducing valvular thickening.
T Homma; S Okudaira; Y Iida
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Research in experimental medicine. Zeitschrift für die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie     Volume:  176     ISSN:  0300-9130     ISO Abbreviation:  Res Exp Med (Berl)     Publication Date:  1980  
Date Detail:
Created Date:  1980-06-16     Completed Date:  1980-06-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0324736     Medline TA:  Res Exp Med (Berl)     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  193-200     Citation Subset:  IM    
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MeSH Terms
Blood Coagulation*
Mitral Valve / physiopathology*
Mitral Valve Insufficiency / physiopathology*
Mitral Valve Stenosis / physiopathology*
Rheumatic Heart Disease / etiology,  physiopathology*
Thromboplastin / analysis
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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