| Studies on the sub-banding of creatine kinase MM and the "CK conversion factor". | |
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MedLine Citation:
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PMID: 6972275 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In serum, the M subunit of creatine kinase (CK) isoenzymes, MM and MB, is modified by a heat labile factor. As a result of the modification three sub-bands of MM and two of MB can be demonstrated by agarose electrophoresis. Normal sera contain MM1 as the dominant sub-band with lesser amounts of MM2 and MM3. Following tissue damage the MM sub-band distribution changes as a result of the increased release of MM, which occurs as MM3. Immediately after coronary bypass surgery MM3 is the dominant sub-band to be replaced by MM2 and in turn by MM1. The factor responsible for the modification of the M subunit, the "CK conversion factor" has been partially purified and its molecular weight determined. |
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Authors:
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H Falter; L Michelutti; A Mazzuchin; W Whiston |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical biochemistry Volume: 14 ISSN: 0009-9120 ISO Abbreviation: Clin. Biochem. Publication Date: 1981 Feb |
Date Detail:
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Created Date: 1981-08-20 Completed Date: 1981-08-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0133660 Medline TA: Clin Biochem Country: CANADA |
Other Details:
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Languages: eng Pagination: 3-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biological Products
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isolation & purification*,
metabolism Chromatography, Ion Exchange Coronary Artery Bypass Creatine Kinase / blood* Electrophoresis, Agar Gel Humans Isoenzymes Molecular Weight Myocardium / enzymology |
| Chemical | |
Reg. No./Substance:
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0/Biological Products; 0/Isoenzymes; EC 2.7.3.2/Creatine Kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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