Document Detail


Studies on the sub-banding of creatine kinase MM and the "CK conversion factor".
MedLine Citation:
PMID:  6972275     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In serum, the M subunit of creatine kinase (CK) isoenzymes, MM and MB, is modified by a heat labile factor. As a result of the modification three sub-bands of MM and two of MB can be demonstrated by agarose electrophoresis. Normal sera contain MM1 as the dominant sub-band with lesser amounts of MM2 and MM3. Following tissue damage the MM sub-band distribution changes as a result of the increased release of MM, which occurs as MM3. Immediately after coronary bypass surgery MM3 is the dominant sub-band to be replaced by MM2 and in turn by MM1. The factor responsible for the modification of the M subunit, the "CK conversion factor" has been partially purified and its molecular weight determined.
Authors:
H Falter; L Michelutti; A Mazzuchin; W Whiston
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical biochemistry     Volume:  14     ISSN:  0009-9120     ISO Abbreviation:  Clin. Biochem.     Publication Date:  1981 Feb 
Date Detail:
Created Date:  1981-08-20     Completed Date:  1981-08-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0133660     Medline TA:  Clin Biochem     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  3-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Biological Products / isolation & purification*,  metabolism
Chromatography, Ion Exchange
Coronary Artery Bypass
Creatine Kinase / blood*
Electrophoresis, Agar Gel
Humans
Isoenzymes
Molecular Weight
Myocardium / enzymology
Chemical
Reg. No./Substance:
0/Biological Products; 0/Isoenzymes; EC 2.7.3.2/Creatine Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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