Document Detail

Studies on steroid fever: I. Production of leukocyte pyrogen in vitro by etiocholanolone.
MedLine Citation:
PMID:  16695933     Owner:  NLM     Status:  PubMed-not-MEDLINE    
When a serum-buffer solution of etiocholanolone is incubated with human blood leukocytes in vitro, a pyrogen is released. Like endogenous pyrogen of leukocyte origin, this pyrogen produces prompt monophasic fevers in rabbits, does not induce fever tolerance when given daily, and is inactivated by trypsin. In many respects, the characteristics of the in vitro reaction resemble experimental steroid-induced fever. For example, release of pyrogen varies directly with the concentration of steroid. 4-8 hr of contact between steroid and leukocyte is required for activation of the cell. Rabbit leukocytes are not activated by etiocholanolone. Finally, androsterone, the 5alpha-isomer of etiocholanolone, does not induce pyrogen release in vitro. These studies suggest that experimental steroid fever in man may be mediated by an endogenous pyrogen released from leukocytes.
P Bodel; M Dillard
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  47     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  1968 Jan 
Date Detail:
Created Date:  2010-06-29     Completed Date:  2010-06-29     Revised Date:  2010-09-15    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  107-17     Citation Subset:  -    
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.
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