Document Detail


Studies of spontaneous fluctuations in congestion and nasal mucosal microcirculation and the effects of oxymetazoline using rhinostereometry and micromanipulator guided laser Doppler flowmetry.
MedLine Citation:
PMID:  10088021     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The mucosa of the inferior turbinate was studied using rhinostereometry and micromanipulator-guided laser Doppler flowmetry in 10 healthy volunteers. First, spontaneous fluctuations were studied measuring congestion and multiple microcirculatory parameters simultaneously every 2 minutes. The subjects were then challenged with oxymetazoline using the same measuring technique studying the effects of the challenge during 12 minutes. There were spontaneous variations in congestion of up to 2.1 mm and variations in perfusion from 38% to 175% of average. There was no correlation between congestion in itself, or change in congestion, to perfusion or any other microcirculatory parameter. After challenge with oxymetazoline there was a rapid decrease in perfusion at 3 minutes after which there were no significant changes. The congestion decreased gradually throughout the procedure. Because congestion reflects the filling of the venous sinusoids and the flowmetry the state of the superficial vessels, we conclude that there are spontaneous short-term fluctuations in the sympathetic tone with independent actions on the different vessels. After challenge with a sympathomimetic drug, there was a decrease in both swelling and flow, but not synchronized. The combination of rhinostereometry and micromanipulator-guided laser Doppler flowmetry is a useful tool to study the dynamics of intranasal challenge reactions.
Authors:
H Grudemo; J E Juto
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American journal of rhinology     Volume:  13     ISSN:  1050-6586     ISO Abbreviation:  Am J Rhinol     Publication Date:    1999 Jan-Feb
Date Detail:
Created Date:  1999-05-10     Completed Date:  1999-05-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8807268     Medline TA:  Am J Rhinol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1-6     Citation Subset:  IM    
Affiliation:
Department of Otorhinolaryngology, Huddinge University Hospital, Karolinska Institute, Stockholm, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Depression, Chemical
Humans
Laser-Doppler Flowmetry / instrumentation,  methods,  statistics & numerical data
Microcirculation / drug effects,  physiology
Nasal Decongestants / pharmacology*
Nasal Mucosa / blood supply*,  drug effects*
Nasal Provocation Tests / instrumentation*,  methods,  statistics & numerical data
Oxymetazoline / pharmacology*
Reference Values
Regional Blood Flow / drug effects
Signal Processing, Computer-Assisted
Statistics, Nonparametric
Time Factors
Chemical
Reg. No./Substance:
0/Nasal Decongestants; 1491-59-4/Oxymetazoline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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