| Studies on spirolactone steroid antagonists in ACTH-induced hypertension in sheep. | |
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MedLine Citation:
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PMID: 2559253 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study investigated the anti-mineralocorticoid potency and haemodynamic effects of a series of mineralocorticoid antagonists of the spirolactone type (RU 28318, spironolactone, K-prorenoate, K-canrenoate and canrenone), for their ability to prevent the development of ACTH-induced hypertension in conscious sheep. In vivo bioassay, using aldosterone dependent changes in parotid salivary [Na+]/[K+] of sodium depleted adrenalectomized sheep, showed spironolactone was the most potent anti-mineralocorticoid tested. Infusions of the antagonists at equal doses alone for 4 days demonstrated that none affected mean arterial pressure, except for K-prorenoate which exhibited slight pressor activity. All the antagonists produced a natriuresis. Some of the steroid antagonists of the spirolactone group blocked the development of ACTH hypertension in sheep, spironolactone being the most effective. This study provides additional evidence for an essential mineralocorticoid component in ACTH-induced hypertension. |
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Authors:
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A F Reid; J P Coghlan; C D Spence; J A Whitworth; B A Scoggins |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of steroid biochemistry Volume: 33 ISSN: 0022-4731 ISO Abbreviation: J. Steroid Biochem. Publication Date: 1989 Dec |
Date Detail:
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Created Date: 1990-02-27 Completed Date: 1990-02-27 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0260125 Medline TA: J Steroid Biochem Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1213-21 Citation Subset: IM |
Affiliation:
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Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Australia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenocorticotropic Hormone Animals Blood Pressure / drug effects Chemical Phenomena Chemistry Electrolytes / blood, urine Female Heart Rate / drug effects Hypertension / chemically induced, physiopathology* Mineralocorticoids / antagonists & inhibitors Saliva / analysis Sheep Spironolactone / antagonists & inhibitors*, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Electrolytes; 0/Mineralocorticoids; 52-01-7/Spironolactone; 9002-60-2/Adrenocorticotropic Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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