| Studies on the specificity of the vaccine effect elicited by inactivated simian immunodeficiency virus. | |
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MedLine Citation:
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PMID: 8427714 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Inactivated, partially purified simian immunodeficiency virus (SIVmac) protected macaques from intravenous challenge with homologous and heterologous strains of SIV that had been grown on human cells but no protection against challenge with monkey peripheral blood mononuclear cell-grown SIVmac was afforded. Human immunodeficiency virus type 1 prepared in an analogous way to the SIVmac vaccine on the C8166 human T cell line protected macaques against challenge with human cell-grown SIVmac. These results suggest that protection may be mediated by xenoimmunization with the vaccine cell substrate proteins. All vaccinated macaques had anti-cell antibodies. Major reactivity to MHC class I antigens was found as well as to a 70-kD protein detectable only under nonreducing conditions. |
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Authors:
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M P Cranage; N Polyanskaya; B McBride; N Cook; L A Ashworth; M Dennis; A Baskerville; P J Greenaway; T Corcoran; P Kitchin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: AIDS research and human retroviruses Volume: 9 ISSN: 0889-2229 ISO Abbreviation: AIDS Res. Hum. Retroviruses Publication Date: 1993 Jan |
Date Detail:
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Created Date: 1993-03-05 Completed Date: 1993-03-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8709376 Medline TA: AIDS Res Hum Retroviruses Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 13-22 Citation Subset: IM; X |
Affiliation:
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Division of Pathology, PHLS Centre for Applied Microbiology & Research, Salisbury, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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AIDS Vaccines
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immunology* Amino Acid Sequence Animals Antibodies, Viral / biosynthesis* Antibody Specificity Cell Line Gene Products, gag / immunology HIV Antibodies / biosynthesis HIV-1 / immunology Histocompatibility Antigens Class I / immunology Histocompatibility Antigens Class II / immunology Humans Macaca mulatta Molecular Sequence Data Simian Acquired Immunodeficiency Syndrome / immunology, prevention & control* Simian immunodeficiency virus / immunology* T-Lymphocytes Vaccines, Inactivated / immunology Viral Vaccines / immunology* |
| Chemical | |
Reg. No./Substance:
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0/AIDS Vaccines; 0/Antibodies, Viral; 0/Gag protein p27, Simian immunodeficiency virus; 0/Gene Products, gag; 0/HIV Antibodies; 0/Histocompatibility Antigens Class I; 0/Histocompatibility Antigens Class II; 0/Vaccines, Inactivated; 0/Viral Vaccines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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