Document Detail

Studies on some biological differences between the chiral forms of methyl-1-naphthyl-p-nitrophenyl phosphorothionate.
MedLine Citation:
PMID:  2580686     Owner:  NLM     Status:  MEDLINE    
A general degranulation test for carcinogens using the postmitochondrial supernatant (PMS) was based on the consistency of the stripping of ribosomes from rough endoplasmic reticulum. The degranulation phenomenon has been classified into three types, which are D1A, D1B and D11. This classification which is new has been introduced to probe more into the mechanistic aspects of degranulation. Aflatoxin B1 dimethylnitrosamine, 2-acetylaminofluorene, and 4-dimethylaminobenzene were carcinogens, evaluated in the PMS system. Reduced glutathione (GSH), oxidized glutathione (GSSG), sodium chloride, potassium chloride, lithium chloride, lithium carbonate, and ascorbic acid which are noncarcinogens and the (+) and (-) chiral forms of methyl-1-naphthyl-p-nitrophenyl phosphorothionate were also evaluated in the PMS system. Lithium carbonate is teratogenic in rats. Similar findings have also been reported in mice, and lithium ion has been confirmed to be teratogenic in mice. This biological phenomenon of the D11 type could well evolve as a teratogenic effect and not a carcinogenic effect.
D A Akintonwa
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article    
Journal Detail:
Title:  Ecotoxicology and environmental safety     Volume:  9     ISSN:  0147-6513     ISO Abbreviation:  Ecotoxicol. Environ. Saf.     Publication Date:  1985 Feb 
Date Detail:
Created Date:  1985-05-30     Completed Date:  1985-05-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7805381     Medline TA:  Ecotoxicol Environ Saf     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  53-63     Citation Subset:  IM    
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MeSH Terms
Aflatoxin B1
Aflatoxins / toxicity
Cytoplasmic Granules / drug effects*
Endoplasmic Reticulum / drug effects
Glutathione / metabolism
Liver / drug effects*
Mitochondria, Liver / drug effects
Organothiophosphorus Compounds / toxicity*
Polyribosomes / drug effects
Proteins / metabolism
RNA / metabolism
Species Specificity
Thiophosphoric Acid Esters / toxicity*
Reg. No./Substance:
0/Aflatoxins; 0/Organothiophosphorus Compounds; 0/Proteins; 0/Thiophosphoric Acid Esters; 1162-65-8/Aflatoxin B1; 63231-63-0/RNA; 68150-94-7/methyl-1-naphthyl-4-nitrophenyl phosphorothionate; 70-18-8/Glutathione

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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