Document Detail

Studies on the role of the preoptic area in the control of reproductive function in the rat.
MedLine Citation:
PMID:  986293     Owner:  NLM     Status:  MEDLINE    
The present study was designed to determine the effects of bilateral lesions restricted to the medial preoptic area on reproductive function in rats. Adult female rats were placed in a stereotaxic instrument, and bilateral lesions were made in the medial preoptic area of the diencephalon using an anodic current and platinum or stainless steel electrodes. Both types of lesions produced identical effects. Most animals with lesions restricted to the medial preoptic area showed repeated periods of pseudopregnancy for the duration of their lives. Ova were detected in the oviducts on the day of estrus between pseudopregnancies, and deciduomata could be produced by uterine traumatization during pseudopregnancy. Daily administration of lergotrile mesylate, a dopamine agonist, for about two weeks, to the pseudopregnant rats with lesions resulted in the appearance of normal 4 or 5-day estrous cycles. These results suggest that the medial preoptic area may not be necessary for ovulation in the rat, and that the normal function of the preoptic area in the control of reproductive cyclicity may be mediated via dopaminergic neurons. In agreement with earlier studies, we found that lesions that extended into the anterior hypothalamus resulted in constant estrus.
J A Clemens; E B Samlstig; B D Sawyer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Endocrinology     Volume:  99     ISSN:  0013-7227     ISO Abbreviation:  Endocrinology     Publication Date:  1976 Sep 
Date Detail:
Created Date:  1976-10-29     Completed Date:  1976-10-29     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0375040     Medline TA:  Endocrinology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  728-35     Citation Subset:  AIM; IM    
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MeSH Terms
Acetonitriles / pharmacology
Ergolines / pharmacology
Estrus / drug effects
Hypothalamus / physiology*,  ultrastructure
Preoptic Area / physiology*,  ultrastructure
Prolactin / antagonists & inhibitors
Reg. No./Substance:
0/Acetonitriles; 0/Ergolines; 9002-62-4/Prolactin

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