Document Detail


Studies on responsiveness of hepatoma cells to catecholamines. IV. Lack of adrenergic activation of phosphorylase in rat ascites hepatoma cells.
MedLine Citation:
PMID:  3795626     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Glycogen phosphorylase a activity in 7 rat ascites hepatoma cell lines treated with adrenergic agents, phenylephrine, epinephrine and isoproterenol, was investigated as compared with that in freshly isolated rat hepatocytes. Basal phosphorylase activities in hepatoma cells except AH7974 cells were lower than that in hepatocytes. Phosphorylase in hepatoma cells was not activated by any of the agents, while the enzyme activity in hepatocytes was clearly increased in a dose- and time-dependent manner. Phosphorylase in hepatocytes was sensitive to glucagon, but it was found to be insensitive to glucagon in all hepatoma cells. The present results suggest that rat ascites hepatoma cells may escape the glycogenolytic regulation by catecholamines and glucagon.
Authors:
K Miyamoto; T Yanaoka; F Sanae; S Wakusawa; R Koshiura
Related Documents :
497206 - Activity of protein synthesis initiation factors in cytosol from rat liver and muscle a...
6451286 - Specificity of pyrimidine nucleoside phosphorylases and the phosphorolysis of 5-fluoro-...
19004006 - Autocrine vegf-a/kdr loop protects epithelial ovarian carcinoma cells from anoikis.
6165706 - Quantitative cytospectrophotometrical determination of the total protein thiols with "m...
291056 - Microinjection of fluorescently labeled alpha-actinin into living fibroblasts.
16024216 - Type ii pneumocytes modulate surfactant production in response to cigarette smoke const...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Japanese journal of pharmacology     Volume:  42     ISSN:  0021-5198     ISO Abbreviation:  Jpn. J. Pharmacol.     Publication Date:  1986 Oct 
Date Detail:
Created Date:  1987-02-19     Completed Date:  1987-02-19     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  2983305R     Medline TA:  Jpn J Pharmacol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  317-20     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Enzyme Activation / drug effects
Epinephrine / pharmacology
Female
Glucagon / pharmacology
Isoproterenol / pharmacology
Liver Neoplasms, Experimental / enzymology*
Phenylephrine / pharmacology
Phosphorylase a / metabolism*
Phosphorylases / metabolism*
Rats
Sympathomimetics / pharmacology*
Chemical
Reg. No./Substance:
0/Sympathomimetics; 51-43-4/Epinephrine; 59-42-7/Phenylephrine; 7683-59-2/Isoproterenol; 9007-92-5/Glucagon; EC 2.4.1.-/Phosphorylase a; EC 2.4.1.-/Phosphorylases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Influence of short-term water deprivation on kinetics of trimethadione and its metabolite in rats.
Next Document:  Further dopaminergic supersensitivity to dopamine agonists by subchronic administration of haloperid...